THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES
SANAD, M., ABO EL MAATY, D., ABD EL-AAL, N., AL-GHANDOUR, A., FARAG, A., YOUSEF, A., FARAG, T. (2020). THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES. EKB Journal Management System, 50(1), 21-32. doi: 10.21608/jesp.2020.88747
MAGDA MOSTAFA SANAD; DALIA ABD EL KHALIK ABO EL MAATY; NAGLAA FATHY ABD EL-AAL; ASMAA M. FAROUK AL-GHANDOUR; AZZA ISMAEL FARAG; ASMAA MOHAMMED YOUSEF; TAHANI ISMAIL FARAG. "THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES". EKB Journal Management System, 50, 1, 2020, 21-32. doi: 10.21608/jesp.2020.88747
SANAD, M., ABO EL MAATY, D., ABD EL-AAL, N., AL-GHANDOUR, A., FARAG, A., YOUSEF, A., FARAG, T. (2020). 'THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES', EKB Journal Management System, 50(1), pp. 21-32. doi: 10.21608/jesp.2020.88747
SANAD, M., ABO EL MAATY, D., ABD EL-AAL, N., AL-GHANDOUR, A., FARAG, A., YOUSEF, A., FARAG, T. THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES. EKB Journal Management System, 2020; 50(1): 21-32. doi: 10.21608/jesp.2020.88747

THERAPUTIC EFFICACY OF PROBIOTICS AGAINST EXPERIMENTAL GIARDIASIS: HISTOPATHOLOGICAL, HISTOCHEMICAL AND ULTRASTRUCTURAL CHANGES

Journal of the Egyptian Society of Parasitology
Article 3, Volume 50, Issue 1, April 2020, Page 21-32  XML PDF (5.83 MB)
Document Type: Original Article
DOI: 10.21608/jesp.2020.88747
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Authors
MAGDA MOSTAFA SANAD1; DALIA ABD EL KHALIK ABO EL MAATY1; NAGLAA FATHY ABD EL-AAL1; ASMAA M. FAROUK AL-GHANDOUR1; AZZA ISMAEL FARAG2; ASMAA MOHAMMED YOUSEF1; TAHANI ISMAIL FARAG3
1Departments of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
2Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
3Departments of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt
Abstract
Giardia lamblia, protozoan intestinal flagellate, is the causative agent of human giardiasis. Currently used therapeutic agents have significant side effects or contraindicated in some clinical conditions and show failure due to drug resistance. This study evaluated the probiotic in vivo-therapeutic efficacy; potent Acidophillus probiotics versus metronidazole against
giardiasis in experimentally infected mice, by histopathological changes of intestinal mucosa, and their impact on the ultrastructure of the pathogenic trophozoites. Forty seven Swiss albino mice were divided into groups: GI: 2 mice non-infected, nontreated mice. GII: 15 mice only infected with G. lamblia cysts, (non-treated). GIII: 15 mice infected and treated orally with potent Acidophillus probiotics. G IV: 15 mice infected with G. lamblia cysts and treated orally with metronidazole. All mice were subjected to parasitological, histo-pathological, goblet cells mucous secreting activity and trophozoite ultrastructural studies. There was high significant difference between the infected non-treated controls and potent Acidophillus-treated group concerning; patent period, infection intensity, reduction percentage of cyst shedding and cure rate, but without significant difference between potent Acidophillus-of treated group and metronidazole-treated group.
Keywords
Giardia lamblia; Swiss albino mice; potent Acidophillus; Ultrastructure; Intestinal Mucus & Histopathology
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