Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity
Amin, A., El-Rifaie, A., Rashed, L., Osman, S. (2020). Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity. EKB Journal Management System, 1(2), 5-11. doi: 10.21608/ejmr.2020.89104
Aya Amin; Abd-ElAziz El-Rifaie; Laila Ahmed Rashed; Shaimaa Taha Osman. "Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity". EKB Journal Management System, 1, 2, 2020, 5-11. doi: 10.21608/ejmr.2020.89104
Amin, A., El-Rifaie, A., Rashed, L., Osman, S. (2020). 'Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity', EKB Journal Management System, 1(2), pp. 5-11. doi: 10.21608/ejmr.2020.89104
Amin, A., El-Rifaie, A., Rashed, L., Osman, S. Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity. EKB Journal Management System, 2020; 1(2): 5-11. doi: 10.21608/ejmr.2020.89104

Vanin-1 Gene Expression in Acne Vulgaris and its Correlation with Disease Severity

Egyptian Journal of Medical Research
Article 1, Volume 1, Issue 2, June 2020, Page 5-11  XML PDF (691.53 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2020.89104
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Authors
Aya Amin* 1; Abd-ElAziz El-Rifaie2; Laila Ahmed Rashed3; Shaimaa Taha Osman1
1Dermatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
2Dermatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
3Biochemistry department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
Background: Acne vulgaris is the most prevalent chronic disease worldwide, occurs during adolescence. The pathogenesis is multifactorial with different grades of severity and the human vanin gene family especially vanin-1 might play a role in pathogenesis of acne. Aim: explore the role of Vanin-1 in acne vulgaris and its correlation with disease severity, duration, weight and residency. Patient and method: 42 acne patients and 42 age and sex matched healthy controls were enrolled. Skin biopsies were taken from the patient and normal skin of controls. Vanin-1 gene expression was estimated by real time PCR. Results: Expression of Vanin-1 gene in acne patients was significantly higher than healthy controls (p-value<0.001), also, there are positive correlation between VNN1 gene expression and patients weight and acne duration (P<0.001), also VNN1 gene expression is significantly higher among urban as compared with rural patients. Conclusion: VNN-1 gene expression is significantly higher in acne patients than healthy controls indicating thatVanin-1 gene involved in pathogenesis of acne vulgaris. In dermatological diseases; Vanin-1 might be a new promising target for therapeutic intervention in acne vulgaris.
Keywords
Vanin-1 Gene; Acne Vulgaris; dermatology
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