Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus
El-Rifaie, A., Rashed, L., Naguib, R., Abdel-Razek, E. (2020). Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus. EKB Journal Management System, 1(2), 25-35. doi: 10.21608/ejmr.2020.89123
Abd-El Aziz Abd-El salam El-Rifaie; Laila Rashed; Rehab Mohamed Naguib; Enas Abdel-Razek. "Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus". EKB Journal Management System, 1, 2, 2020, 25-35. doi: 10.21608/ejmr.2020.89123
El-Rifaie, A., Rashed, L., Naguib, R., Abdel-Razek, E. (2020). 'Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus', EKB Journal Management System, 1(2), pp. 25-35. doi: 10.21608/ejmr.2020.89123
El-Rifaie, A., Rashed, L., Naguib, R., Abdel-Razek, E. Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus. EKB Journal Management System, 2020; 1(2): 25-35. doi: 10.21608/ejmr.2020.89123

Study of Expression of Suppressor of Cytokine Signaling 3 in Lichen Planus

Egyptian Journal of Medical Research
Article 3, Volume 1, Issue 2, June 2020, Page 25-35  XML PDF (664.26 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2020.89123
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Authors
Abd-El Aziz Abd-El salam El-Rifaie1; Laila Rashed2; Rehab Mohamed Naguib3; Enas Abdel-Razek* 1
1Department of Dermatology - Faculty of Medicine Beni-Suef University, Egypt.
2Department of Biochemistry - Faculty of Medicine- Cairo University, Egypt.
3aDepartment of Dermatology - Faculty of Medicine Beni-Suef University, Egypt.
Abstract
Background: Lichen planus (LP) is a mucocutaneous disease that is relatively common between adult populations. LP can present as skin and oral lesions. Objective: The present study aimed to detect the expression of SOCS3 in lichen planus of diseased patients as compared to normal control persons. Patients and methods: This study was a case control study included 30 Lichen planus patients as cases chosen from outpatients attending Dermatology Department at Beni- Suef University Hospital and 30 normal as controls calculated by sample size calculator formula. Results: In our study, LP cases and control were compared using SOCS3; to determine the cut-off value, we performed a ROC analysis. SOCS3 has perfect value for discrimination between LP cases and controls with an area under the ROC curve of 1.0 (95% CI = 0.940 to 1.000, P-value <0.0001). Best cut-off is a value of 1.5 (sensitivity = 100%, specificity = 1.0, J-index = 1.0). Conclusion: Our results were unique in studying the role of SOCS3 in skin form of LP. SOCS3 has perfect value for discrimination between LP cases and controls.
Keywords
Suppressor of Cytokine Signaling 3; Lichen Planus
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