EFFECT OF SOME HYDROXYLATED ADDITIVES ON THE MICELLAR SOLUBILIZATION OF METHOTRIMEPRAZINE | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 7, Issue 1, June 1984, Page 97-108 PDF (376.05 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1984.89533 | ||||
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| Authors | ||||
| A. E. Aboutaleb; M. S. Mesiha; A. Abdel-Zaher | ||||
| Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| The effect of different hydroxylated compounds on the solubility of Methotrimeprazine in non-ionic surfactant solutions was investigated at two different temperatures. Ethanol, glycerol, polyethylene glycol (PEG) 600 and PEG 4000, mannitol and sorbitol were studied as additives in systems containing Eumulgin C 1000, Eumulgin C 1500, Brij 35 and Brij 58 as the solubilizing surfactants. Micellar solubilization of Methotrimeprazine was found to be increased in Brij 35 systems with all additives except at low concentration (5% w/v) of PEG 600. It also increased in systems of Brij 58 containing PEG 600, PEG 4000, mannitol and sorbitol. A marked decrease in micellar solubilization of the drug was effected in systems of Eumulgine and Brij-58 containing ethanol or glycerol due to decreased micellization. Also, PEG 4000, mannitol and sorbitol decreased solubilizing effect of Eumulgine, except for PEG 4000 with Eumulgin C1000 at 35°. | ||||
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