TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY
HAMZA, H., EL-TAWEEL, H., ABOU-HOLW, S., KHALIL, S., WAGDY, E. (2015). TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY. EKB Journal Management System, 45(1), 7-15. doi: 10.21608/jesp.2015.89674
HAJAR HAMZA; HEND EL-TAWEEL; SAHAR ABOU-HOLW; SAFIA KHALIL; EMAN WAGDY. "TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY". EKB Journal Management System, 45, 1, 2015, 7-15. doi: 10.21608/jesp.2015.89674
HAMZA, H., EL-TAWEEL, H., ABOU-HOLW, S., KHALIL, S., WAGDY, E. (2015). 'TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY', EKB Journal Management System, 45(1), pp. 7-15. doi: 10.21608/jesp.2015.89674
HAMZA, H., EL-TAWEEL, H., ABOU-HOLW, S., KHALIL, S., WAGDY, E. TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY. EKB Journal Management System, 2015; 45(1): 7-15. doi: 10.21608/jesp.2015.89674

TOXOPLASMA GONDII SEROPOSITIVITY IN RENAL PATIENTS: RATE, PATTERN, PREDICTORS AND RELATED MORBIDITY

Journal of the Egyptian Society of Parasitology
Article 2, Volume 45, Issue 1, April 2015, Page 7-15  XML PDF (245.6 K)
Document Type: Original Article
DOI: 10.21608/jesp.2015.89674
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Authors
HAJAR HAMZA1; HEND EL-TAWEEL2; SAHAR ABOU-HOLW2; SAFIA KHALIL2; EMAN WAGDY3
1Clinical Laboratories, Alexandria Main University Hospital, Medical Research Institute, Alexandria University, Egypt.
2Department of Parasitology, Medical Research Institute, Alexandria University, Egypt.
3Department of Internal Medicine, Medical Research Institute, Alexandria University, Egypt.
Abstract
Infection is a significant cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to their depressed immunity. T.gondii is a ubiquitous parasite that causes severe manifestations in immunocomprmised patients. The present study investigated rate, pattern, predictors and related morbidity of T. gondii seropositivity in CKD patients.
The study included four groups: i-patients on maintenance hemodialysis (HD; n = 60); iipatients with systemic lupus erythematosus on immunosuppressive therapy for lupus nephritis (SLE; n=30) iii- Renal transplant recipients (RTR; n=30) and iv- healthy controls (HC; n = 30). Anti-Toxoplasma IgG, IgM & IgG avidity were determined using enzyme immunoassays. Patients' medical data and information on plausible risk factors for toxoplasmosis were recorded. Results revealed that T.gondii seropositivity rates in HD, SLE and RTR groups (61.7, 60 & 70% respectively) were significantly high compared to HC (30 %). Among seropositive patients, 79% of those with negative IgM displayed high IgG avidity confirming past infection. None of IgM positive patients had low IgG avidity. The latter was detected in some IgM negative patients. Multivariate analysis showed that seropositivity was significantly associated with undercooked meat consumption (adjusted OR= 6.256, CI= 2.167-18.056) and blood transfusion (adjusted OR = 5.953, CI= 2.987-11.864).
No significant association could be found between T. gondii seropositivity and the clinical manifestations of CKD patients.
Keywords
T. gondii; chronic kidney disease; IgG avidity; undercooked meat; blood transfusion
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