FORMULATION AND STABILITY OF HEPTAMINOL SUPPOSITORIES PART III: Chemical Stability of Heptaminol Suppositories | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 5, Volume 7, Issue 2, December 1984, Page 288-294 PDF (282.6 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1984.89702 | ||||
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| Authors | ||||
| Ali A. Kassem; Mohamed F. El-Miligi; Siham A. Ali | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| The chemical stability of Heptaminol base in four different suppository bases was investigated in absence and presence of several stabilizers. The stability was found decreasing in the order of: Glycerogelatin, Cacao-Butter, Witepsol-E-75, and then Polyethylene-Glycols. Butylated hydroxyanisol (BHA) was the best stabilizer in the two fatty-based formulae, while tocopherol succinate was the worst. In the water-soluble bases, sodium thiosulphate was the best stabilizer, while the mixture of sodium formaldehyde sulfoxylate (SFS) with sodium edentate was the worst. | ||||
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