STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA
IBRAHIM, A., ABDEL ALEEM, M., ABDELLA, H., HELMY, A. (2015). STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA. EKB Journal Management System, 45(1), 107-113. doi: 10.21608/jesp.2015.89706
AMANY AHMAD IBRAHIM; MOSTAFA HAMED ABDEL ALEEM; HEBA MOHAMED ABDELLA; AMIR HELMY. "STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA". EKB Journal Management System, 45, 1, 2015, 107-113. doi: 10.21608/jesp.2015.89706
IBRAHIM, A., ABDEL ALEEM, M., ABDELLA, H., HELMY, A. (2015). 'STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA', EKB Journal Management System, 45(1), pp. 107-113. doi: 10.21608/jesp.2015.89706
IBRAHIM, A., ABDEL ALEEM, M., ABDELLA, H., HELMY, A. STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA. EKB Journal Management System, 2015; 45(1): 107-113. doi: 10.21608/jesp.2015.89706

STUDY OF THE ROLE OF INSULIN RESISTANCE AS A RISK FACTOR IN HCV RELATED HEPATOCELLULAR CARCINOMA

Journal of the Egyptian Society of Parasitology
Article 14, Volume 45, Issue 1, April 2015, Page 107-113  XML PDF (184.56 K)
Document Type: Original Article
DOI: 10.21608/jesp.2015.89706
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Authors
AMANY AHMAD IBRAHIM1; MOSTAFA HAMED ABDEL ALEEM1; HEBA MOHAMED ABDELLA1; AMIR HELMY2
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
Abstract
Chronic HCV infection causes hepatic cirrhosis and approximately 10%-20% of cirrhotic patients may develop hepatocellular carcinoma within 5 years. Diabetes mellitus is associated with a 2-4-fold increase in the risk of HCC. Insulin resistance (IR) emerged as a risk factor for a variety of cancers, including endometrial and breast and various gastrointestinal cancers. The role of IR in the development of HCC associated with chronic HCV infection has not been established. This study elucidated the role of insulin resistance assessed by the homeostasis model (HOMA-IR) in development of hepatocellular carcinoma associated with chronic hepatitis C infection. The study included 3 groups: GI: 100 newly diagnosed cases of HCV related hepatocellular carcinoma GII: 60 patients with HCV related chronic liver disease. Forty healthy persons as a control group (GIII). All groups were subjected to full history taking, physical examination, laboratory investigations abdominal ultrasonography and Triphasic C.T examination. In addition to Calculation of Body mass Index, Measurement of fasting blood insulin and glucose, Calculation of insulin resistance using HOMA-IR. The results showed that fasting insulin and HOMA-IR were significantly higher among HCC group than HCV
group & control group. Also, fasting insulin and HOMA-IR were significantly higher in HCV group than control group. HOMA-IR above 3.7, insulin above 9μU/L & DM were considered independent predictors of HCC.
Keywords
Hepatocellular carcinoma; Diabetes mellitus; Insulin resistance
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