SOLUBILIZATION AND STABILITY OF PYRIDINE-3-CARBOXALDHYDE THIOSEMICARBAZONE BY DIFFERENT MICELLAR FORMING MATERIALS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 8, Volume 7, Issue 2, December 1984, Page 322-337 PDF (516.34 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1984.89713 | ||||
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| Authors | ||||
| A. P. Simonelli1; A. E. Aboutaleb2; A. A. Abdel-Rahman2 | ||||
| 1School of Pharmacy, University of Connecticut, STORRS, CT 06268, U.S.A | ||||
| 2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Pyridine-3-Carboxaldhyde thiosemicarbazone (P3CTZ) used in cancer therapy was solubilized by anionic cationic and nonionic surfactant solutions of pH 5,6,7,8 and ionic strength (u) of 0.2 at 47. So sodium dodecyl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB) and Brij 35 were chosen to represent the last three classes respectively. It was found that SDS has the highest solubilizing efficiency toward P3CTZ followed by Brij 35 and CTAB respectively at all pH values studied. . The stability of P3CTZ was studied in different concentrations of surfactants at pH values of 5,6,7 and 8 and u of 0.2. It was found that the longest t½ observed was in Brij 35 solution of pH 5 at 47° (nearly t½ equal one year). The shortest t½ was found in CTAB solutions. It was found also that the partition coefficient from solubility slightly higher than that obtained from stability measurements. It was concluded that the stability of P3CTZ is greater relatively at higher pH values, than at lower pH values as reported by other workers. | ||||
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