AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA
SABRY, A., ABD EL-AAL, A., MAHMOUD, N., NABIL, Y., ABDEL AZIZ, I. (2015). AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA. EKB Journal Management System, 45(2), 233-240. doi: 10.21608/jesp.2015.89810
ABD EL HAMID A. SABRY; AMANY A. ABD EL-AAL; NAGLAA SAAD MAHMOUD; YOSSRA NABIL; INAS Z. ABDEL AZIZ. "AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA". EKB Journal Management System, 45, 2, 2015, 233-240. doi: 10.21608/jesp.2015.89810
SABRY, A., ABD EL-AAL, A., MAHMOUD, N., NABIL, Y., ABDEL AZIZ, I. (2015). 'AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA', EKB Journal Management System, 45(2), pp. 233-240. doi: 10.21608/jesp.2015.89810
SABRY, A., ABD EL-AAL, A., MAHMOUD, N., NABIL, Y., ABDEL AZIZ, I. AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA. EKB Journal Management System, 2015; 45(2): 233-240. doi: 10.21608/jesp.2015.89810

AN INITIAL INDICATION OF PREDISPOSING RISK OF SCHISTOSOMA MANSONI INFECTION FOR HEPATOCELLULAR CARCINOMA

Journal of the Egyptian Society of Parasitology
Article 3, Volume 45, Issue 2, August 2015, Page 233-240  XML PDF (3.55 MB)
Document Type: Original Article
DOI: 10.21608/jesp.2015.89810
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Authors
ABD EL HAMID A. SABRY1; AMANY A. ABD EL-AAL2; NAGLAA SAAD MAHMOUD2; YOSSRA NABIL3; INAS Z. ABDEL AZIZ2
1Department Medical Parasitology, Faculty of Medicine, Al-Fayoum University, Egypt.
2Department Medical Parasitology, Faculty of Medicine, Cairo University, Egypt.
3Department Medical Parasitology, Faculty of Medicine, Al-Fayoum University.
Abstract
Estimated 500,000 - 1 million cases of hepatocellular carcinoma (HCC) are reported to occur yearly worldwide, with a mean annual incidence of around 3 – 4% of global population. HCC is rapidly fatal in most patients; that makes its incidence and mortality rates almost equal. In the last 5–10 years there were many alarming reports of sharply increased incidence of HCC. In Egypt, HCC reported to account for about 4.7% of chronic liver disease (CLD) patients, which has tremendous impact on socio-economic development in the country. Available data suggests indirect evidence of an association between Schistosoma mansoni and hepatocellular carcinoma, possibly through potentiation of hepatitis infections. The present study was conducted case control analysis of 60 HCC patients. Chronic schistosomiasis cases were confirmed by finding Anti-Schistosoma mansoni antibodies IgG by ELISA. Hepatitis C viral infection was proved by detection of viral load by quantitative Real time PCR. Among the study group 56.6% (34/60) were dweller in rural in Al-Fayoum governorate. Within hepatocellular carcinoma cases 26.7% (16/60) and 33.3% (20/60) suffered mono chronic schistosomiasis and mono hepatitis C (HCV) infections respectively, with no statistically significant differences (p=0.37), indicating comparable risk value of both infections in predisposing directly to HCC. Additionally; frequency of HCC patients with assumed potentiated HCV infection by chronic Schistosoma mansoni 6.7% (4/60) were statistically significant (p<0.05) less among total HCC patients included in this study, when compared to HCC patients preceded by either pure chronic schistosomiasis 26.7% (16/60) or pure HCV infection 33.3% (20/60). Our present study is one of few, addressing the possibility of direct relation between S. mansoni & hepatic carcinoma, concluding an initial indication of equal risk value of both human chronic S. mansoni infection and hepatitis C viral infections in precipitating hepatocellular carcinoma among Egyptian patients.
Keywords
Patients; Schistosoma mansoni; hepatitis C; hepatocellular carcinoma
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