VEHICLE INFLUENCE ON OCULAR DISPOSITION OF CHLORTETRACYCLINE HYDROCHLORIDE AND CHLORAMPHENICOL IN THE ALBINO RABBIT | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 15, Volume 7, Issue 2, December 1984, Page 418-429 PDF (392.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.1984.89872 | ||||
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| Authors | ||||
| M. A. Attia; H. A. El-Sourady; S. M. El-Shanawany | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut , Egypt | ||||
| Abstract | ||||
| The effect of four bases on the ocular disposition of chloramphenicol and chlortetracycline hydrochloride in the albino rabbits was investigated. It was found that the highest concentration of chlortetracycline hydrochloride in conjunctiva and cornea obtained from absorption base (A) and emulsion base (C). The absorption base (B) and emulsion base (C) were the only bases that can penetrate through the cornea into aqueous humor and irisciliary body. The emulsion base (D) give the highest chloramphenicol concentration in the conjunctiva in comparison with the other bases studied. Chloramphenicol appeared to be rapid uptake from all formulations and distributed across the cornea to the anterior chamber. Chloramphenicol uptake by conjunctiva from two emulsion bases (C and D) was more than from the other two absorption bases (A&B). | ||||
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