WITHANOLIDES OF WITHANIA SOMNIFERA L. DUNAL GROWING WILD IN EGYPT | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 16, Volume 7, Issue 2, December 1984, Page 430-443 PDF (474.54 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.1984.89873 | ||||
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Authors | ||||
M. M. El-Olemy1; H. A. Kadry2 | ||||
1Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt | ||||
2Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt | ||||
Abstract | ||||
Three Withanolides (Substances A,B, and C) were isolated from the alcoholic extract of the Egyptian Withania somnifera wild plants. Substance A and substance C were identified by IR, NMR and Mass spectral data. Substance A appears to be a configurational isomer of Withanolide E and substance C is 4-hydroxy derivative of substance A. Substance A is identified as 14,17,20-trihydroxy-5B,6B-epoxy-1-oxo-Witha-2,24-dienolide (I) and substance C as 4,14,17,20-tetrahydroxy-5B, 6B-epoxy-1-oxo-witha-2,24-dienolide(II). This is the first report of isolation and characterization of substance C from Withania somnifera or the genus Withania. Substance B would be the subject of a further report. | ||||
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