NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS
El Ray, A., Azab, M., Abd El-Aleem, A., El-Talkawy, M., Abd El-Badea, M., El Ansary, M., Saleem, A., Diab, T. (2015). NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS. EKB Journal Management System, 45(2), 421-428. doi: 10.21608/jesp.2015.89956
Ahmed El Ray; Mohamed Mohamed Azab; Ahmed Abd El-Aleem; Mohamed Darwish El-Talkawy; Mohamed Abd El-Hameed Abd El-Badea; Mahmoud El Ansary; Abdelaziz Ali Saleem; Tarek Mahmoud Diab. "NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS". EKB Journal Management System, 45, 2, 2015, 421-428. doi: 10.21608/jesp.2015.89956
El Ray, A., Azab, M., Abd El-Aleem, A., El-Talkawy, M., Abd El-Badea, M., El Ansary, M., Saleem, A., Diab, T. (2015). 'NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS', EKB Journal Management System, 45(2), pp. 421-428. doi: 10.21608/jesp.2015.89956
El Ray, A., Azab, M., Abd El-Aleem, A., El-Talkawy, M., Abd El-Badea, M., El Ansary, M., Saleem, A., Diab, T. NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS. EKB Journal Management System, 2015; 45(2): 421-428. doi: 10.21608/jesp.2015.89956

NON-INVASIVE PREDICTORS FOR THE PRESENCE, GRADE AND RISK OF BLEEDING FROM ESOPHAGEAL VARICES IN PATIENTS WITH POST-HEPATITIC CIRRHOSIS

Journal of the Egyptian Society of Parasitology
Article 23, Volume 45, Issue 2, August 2015, Page 421-428  XML PDF (11.54 MB)
Document Type: Original Article
DOI: 10.21608/jesp.2015.89956
View on SCiNiTO View on SCiNiTO
Authors
Ahmed El Ray1; Mohamed Mohamed Azab2; Ahmed Abd El-Aleem2; Mohamed Darwish El-Talkawy3; Mohamed Abd El-Hameed Abd El-Badea3; Mahmoud El Ansary3; Abdelaziz Ali Saleem3; Tarek Mahmoud Diab4
1Department of Hepatogastroenterology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
2Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
3Department of Hepatogastroenterology, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Giza, Egypt.
4Department of Parasitology, Theodor Bilharz Research Institute, Imbaba P. O. Box 30, Giza, Egypt.
Abstract
Variceal bleeding is the last step of a chain of events initiatedby an increase in portal pressure, followed by the development and progressive dilation ofvarices until these finally rupture and bleed. The ideal method to diagnose portal hypertension should be accurate, noninvasive, objective, and reproducible. The study evaluated the predictive value of two non-invasive parameters for the diagnosis of esophageal varices (EV): 1- Right liver lobe diameter/serum albumin ratios (RLLD /S. albumin), and 2- Platelet count/splenic bipolar diameter ratios (Platelets count/SBPD). This study included eighty Egyptian patients with post-hepatitic cirrhosis (45males and 35 females). They underwent laboratory ultrasono-graphic and endoscopic examinations within one week. RLLD/S. albumin and Platelets count/SBPD ratios were calculated. The results showed that EV were not detected by upper digestive endoscopy in 25%, while grade I of EV was
found in 17.5%, grade Ⅱ in 17.5%, grade Ⅲ in 20%, & grade Ⅳ in 20%. RLLD/S. albumin concentration ratio diagnosed the varices at cut off value of 3.43 with 95% sensitivity and 80% specificity. Also, it was positively correlated with grading of E.V, when this ratio increased the grading of E.V increases and vice versa. Besides, it predicted bleeding from E.V. at cut off value of 5.096 with 63% sensitivity and 73% specificity. Platelet count/ SBPD ratio predicted the presence of varices at cut off value 1847 with 95% sensitivity and 93% specificity, and negatively correlated with grading of EV, when this ratio decreased grading of E.V increase and vice versa. It also predicted bleeding from E.V. at cut off value of 4809 with 50% sensitivity and 93% specificity.
Keywords
Right liver lobe diameter; esophageal varices; platelet count; splenic bipolardiameter
Statistics
Article View: 63
PDF Download: 117