L-CARNITINE, A NEW PROSPECTIVE PROMOTE RECOVERY FROM ACRYLAMIDE NEUROTOXICITY IN RATS | ||||
| Journal of Agricultural Chemistry and Biotechnology | ||||
| Article 5, Volume 1, Issue 7, July 2010, Page 409-423 PDF (772.92 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jacb.2010.90047 | ||||
 View on SCiNiTO | ||||
| Author | ||||
H. I. Mahmoud 
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| Agric. Chem. Dept., Faculty of Agriculture, Minia Univ., Minia, Egypt | ||||
| Abstract | ||||
| L-carnitine (4-N-trimethylammonium-3-hydroxybutyric acid) proved to be an important factor in human nutrition. It synthesizes from dietary amino acids and widely distributed in the body. Research works on the ability of carnitine in protecting biological systems against acrylamide. Acrylamide (AA) C3H5NO the chemical with many industrial and laboratory uses is a neurotoxicant and carcinogen agent as proved in literatures. Research has pointed to L-carnitine role in recovering AA toxicity. Three days per week, L-carnitine (300 mg/kg b.w.) was administrated orally followed on the second day by treatment with 50, 200 or 500 mg acrylamide/L in drinking water. Up to 5 weeks, L-carnitine improved feed efficiency with decreasing daily body weight gain with 50 mg AA/L. L-carnitine showed approximate success in keeping liver and testis weight comparing to normal group. L-carnitine showed amelioration in vitamin C and serum glucose in 50 mg/L AA. L-carnitine ameliorated lipid profile and risk factor LDL/HDL ratio especially with 50 mg/L AA. On the other side, AA concentrations showed highly effects on liver functions, total antioxidant, reduced glutathione and cholinesterase activity to the point where L-carnitine failed to face. | ||||
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