The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.
Mohamed, H., Anwar, R. (2019). The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.. EKB Journal Management System, 42(2), 120-136. doi: 10.21608/ejana.2019.10703.1016
Heba Kamal Mohamed; Rasha Ibrahim Anwar. "The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.". EKB Journal Management System, 42, 2, 2019, 120-136. doi: 10.21608/ejana.2019.10703.1016
Mohamed, H., Anwar, R. (2019). 'The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.', EKB Journal Management System, 42(2), pp. 120-136. doi: 10.21608/ejana.2019.10703.1016
Mohamed, H., Anwar, R. The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.. EKB Journal Management System, 2019; 42(2): 120-136. doi: 10.21608/ejana.2019.10703.1016

The possible role of folic acid against sodium fluoride induced toxicity in the skin of adult male albino rats.

The Egyptian Journal of Anatomy
Article 4, Volume 42, Issue 2, July 2019, Page 120-136  XML PDF (9.22 MB)
Document Type: Original Article
DOI: 10.21608/ejana.2019.10703.1016
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Authors
Heba Kamal Mohamed email orcid 1; Rasha Ibrahim Anwar2
1Department of Human Anatomy and Emberyology, Faculty of Medicine, Assiut University, Assiut, Egypt
2Department of Human Anatomy and Emberyology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Abstract
Background:Exposure of human being to fluoride occurs through various sources as food, water, toothpastes and fluoride additives. This exposure is either to low concentrations for long periods or to high concentrations and both may lead to poisoning.  Folic acid (FA) has an important free radical scavenging property which makes it the most potent antioxidants. Moreover, it suppresses apoptosis and boost cell survival.
Aim of the work: To evaluate the protective and therapeutic role of FA against sodium fluoride (NaF) induced toxicity on adult male rat skin.
Materials and Methods:Forty adult (3 months) male albino rats(weighing 200-220 gm) were equally divided into 4 groups (10 rats each):group 1 (control),group 2 (NaF, for 4 weeks),group 3 (NaF, for 4 weeks followed by FA for another 4 weeks) and group 4 (NaF plus FA for 4 weeks). Both NaF (25mg/Kg b.w.) and FA (8 mg/Kg b.w.) were given orally daily. The rats were sacrificed and samples of the back skin were processed for histological, immunohistochemical (Bcl2 antiapoptotic protein) and morphometric studies.
Results:Group 2 revealed signs of degeneration in epidermal cells, expansion of intercellular spaces and destructed organelles. There wasa reduction in epidermal thickness with disturbance in collagen fibers arrangement and weak immunoreactivity of Bcl-2. FA induced relative improvement in the dermal and epidermal structures in group 3 while there was preservation of these structures in group 4.
Conclusion:FA ameliorates NaF induced harmful effects on skin in addition to its valuable preventive role.
Keywords
FA; NaF; Skin; rat
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