CYTOKINES AND MOTHER SPOROCYSTS IN SUSCEPTIBLE AND RESISTANT BULINUS TRUNCATUS SNAILS INFECTED WITH SCHISTOSOMA HAEMATOBIUM | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 1, Volume 44, Issue 2, August 2014, Page 285-293 PDF (255.76 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2014.90379 | ||||
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| Authors | ||||
| ABDEL HAKIM SAAD EL-DIN1; FATHIYA ALI GAWISH2; HANAA MOHAMED ABU EL EININ2; SHEREEN MAHFOUZ MANSOUR2 | ||||
| 1Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt. | ||||
| 2Department of Environmental Research and Medical Malacology, Theodor Bilharz Research Institute, PO Box 30, Imbaba, Giza, Egypt. | ||||
| Abstract | ||||
| The presence of immunoreactive interleukin (IL-2), interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) in addition to the citation of mother sporscytes in cephalopodal musculature in the susceptible and resistance Bulinus truncatus the specific intermediate host for the trematode Schistosoma haematobium were investigated,. Using ELISA tests, Results indicated that the concentration of IL-2-like activity in the susceptible and resistant snails decreased significantly after infection then persisted at low levels until the 4th week post exposure (WPE) in susceptible snails, while in resistant snails elevated during the second WPE, and returned to initial level at 3 and 4 WPE. Susceptible snails had low detectable levels of TNF-α and INF- like-activity after infection. However, the resistant snails had significant low levels of TNF-α and INF- like-activity from 3 WPE until the 4th WPE without any sign of normalization. Histological sections in the head- foot region of susceptible and resistance B. truncatus infected with S. haematobium, mother sporocysts exists from1 to 7(day post exposure) DPE, in the susceptible snail the mother sporocysts were found as single, multiple and mature types. No mother sporocysts were appear in the lip and mantle of the snail on 2, 5, 7 DPE and on 1-3 , 6 DPE respectively. In the resistant snails few mother sporocysts were found in the lip, mantle and tentacles. The results showed that schistosome-resistant Bulinus can be an alternative strategy for the control of schistosomiasis. | ||||
| Keywords | ||||
| Bulinus truncatus; cytokine Schistosoma haematobium; sporocyst; susceptible; resistant | ||||
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