PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS
SEIF EL-DIN, S., SABRA, A., HAMMAM, O., EBEID, F., EL-LAKKANY, N. (2014). PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS. EKB Journal Management System, 44(2), 295-308. doi: 10.21608/jesp.2014.90380
SAYED H. SEIF EL-DIN; ABDEL-NASSER A. SABRA; OLFAT A. HAMMAM; FATMA A. EBEID; NAGLAA M. EL-LAKKANY. "PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS". EKB Journal Management System, 44, 2, 2014, 295-308. doi: 10.21608/jesp.2014.90380
SEIF EL-DIN, S., SABRA, A., HAMMAM, O., EBEID, F., EL-LAKKANY, N. (2014). 'PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS', EKB Journal Management System, 44(2), pp. 295-308. doi: 10.21608/jesp.2014.90380
SEIF EL-DIN, S., SABRA, A., HAMMAM, O., EBEID, F., EL-LAKKANY, N. PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS. EKB Journal Management System, 2014; 44(2): 295-308. doi: 10.21608/jesp.2014.90380

PHARMACOLOGICAL AND ANTIOXIDANT ACTIONS OF GARLIC AND/OR ONION IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN RATS

Journal of the Egyptian Society of Parasitology
Article 2, Volume 44, Issue 2, August 2014, Page 295-308  XML PDF (832.88 K)
Document Type: Original Article
DOI: 10.21608/jesp.2014.90380
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Authors
SAYED H. SEIF EL-DIN1; ABDEL-NASSER A. SABRA1; OLFAT A. HAMMAM2; FATMA A. EBEID1; NAGLAA M. EL-LAKKANY1
1Department of Pharmacology, Theodor Bilharz Research Institute, Warak El- Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt.
2Department of Pathology, Theodor Bilharz Research Institute, Warak El- Hadar, Imbaba, P.O. Box 30, Giza 12411, Egypt.
Abstract
Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of fat-induced liver injury, ranging from mild steatosis to cirrhosis and liver failure. This study investigates the hepatoprotective properties of garlic and onion in NAFLD rat model. Ninety male Sprague- Dawley rats were randomly divided into 9 groups; normal (I), NAFLD induced with high fat diet (HFD; II), NAFLD switched to regular diet (RD; III), NAFLD-HFD or NAFLD-RD treated with garlic (IV, V), onion (VI, VII) or the combined garlic+onion (VIII, IX) respectively. A NAFLD rat model was established by feeding the animals with a high-fat diet for 12 wk. These animals were then treated with garlic or/and onion or vehicle for 8 wk (weeks 13-20) and then killed to obtain serum samples and liver tissues. Liver histology, lipids, parameters of oxidative stress, TNF- and TGF- were measured. The liver in NAFLD-HFD showed typical steatosis, accompanied with mild to moderate lobular inflammatory cell infiltration. Serum levels of ALT, AST, ALP, leptin, cholesterol, triglycerides, TNF-α, TGF- and hepatic MDA were significantly increased (P<0.05) compared with normal group. This was accompanied with reduction of hepatic
GSH, GR, GPx, GST, SOD and serum adiponectin. These changes were to a less degree in NAFLD-RD group. Combined administration of garlic+onion produced a better and significant decrease in liver steatosis, serum liver enzymes, oxidative markers and lipid peroxidation versus each one alone. In the same time, NAFLD-induced inflammation was also mitigated via reduction of TNF- and TGF-. In addition, these results were better in the group IX versus group VIII.
Keywords
Fatty liver; garlic; onion, leptin; adiponectin; TGF-; TNF-; liver enzymes and antioxidants
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