ROLE OF CEREBROSPINAL FLUID IL-8 AS A MARKER FOR DIFFERENTIATION BETWEEN ACUTE BACTERIAL AND ASEPTIC MENINGITIS | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 21, Volume 44, Issue 1, April 2014, Page 205-210 PDF (213.32 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2014.90739 | ||||
View on SCiNiTO | ||||
Authors | ||||
AMAL TOHAMY ABDELMOEZ1; DOAA ZAKARIA ZAKY1; AMANY M. MAHER2 | ||||
1Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo11566, Egypt. | ||||
2Medical Research Center, Molecular Biology Unit, Ain Shams University, Cairo11566, Egypt. | ||||
Abstract | ||||
No doubt, the distinguishing between bacterial and aseptic meningitis in the emergency department could help to limit unnecessary antibiotic use and hospital admissions. This study evaluated the role of cerebrospinal fluid IL-8 in differentiating acute bacterial meningitis (ABM) from aseptic meningitis (AM). A total of 80 hospitalized patients with clinical presentations of suspected acute meningitis were subjected to estimation of IL-8 CSF concentrations. The results showed that CSF IL-8 levels were higher in acute bacterial meningitis than in aseptic ones (p <0.05). The best cut-off value of CSF IL8 for early diagnosis of bacterial meningitis was 3.6ng/ml with a sensitivity of 82.5% and a specificity of 85.0%. | ||||
Keywords | ||||
Egypt; Acute Bacterial; Aseptic Meningitis; Marker; Cerebrospinal Fluid Il-8 | ||||
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