Evaluation of Polymorphnuclear Leucocyte Elastase as Diagnostic Tool in Neonatal Sepsis | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 23, Volume 72, Issue 2, July 2018, Page 4000-4004 PDF (218.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.9087 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| 1Bothina Mohamed Abdel-Aziz El-Nagar, 1Soheir Ibrahim Mohamed, 2Sabah Ibrahim Abdelrahim, 1Mohamed Abdel-Gawad Morsy | ||||
| 1Department of Pediatrics, 2Department of Clinical Pathology, Faculty of Medicine for Girls - Al Azhar University | ||||
| Abstract | ||||
| Objectives: Neonatal sepsis is clinical syndrome of bacteremia with systemic signs and symptoms. Neonatal sepsis is still a leading cause of mortality in neonatal intensive care units all over the world. Early diagnosis and treatment of the newborn infant with suspected sepsis are essential to prevent severe and life threatening complications. Objective: The aim of this study was to evaluate polymorph nuclear (PMN) leucocyte elastase as a diagnostic tool in neonatal sepsis. Subjects and Methods: This study was conducted on 45 full term and preterm neonates suspected as neonatal sepsis compared to 45 apparently healthy neonate with matched age and sex, as a control group. Results: 55.6% of our patients group were full-term patients and 44.4% were preterm. All the patients were subjected to full history taking, full clinical examination, lab investigation including CBC, CRP, blood culture and sensitivity, and measurement of serum polymorph nuclear leucocyte elastase enzyme. Conclusion: Significant elevation of serum polymorph nuclear leucocyte elastase level in neonatal sepsis with high specificity. | ||||
| Keywords | ||||
| Polymorphonuclear leucocyte; Escherichia coli; Early onset sepsis; Late onset sepsis | ||||
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