Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 19, Volume 72, Issue 3, July 2018, Page 4148-4153 PDF (351.76 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.9131 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Fawzia Khalil1, Hanan H. Shehata1, Nehad Osman2, Omar Abdel-Rahman3, Marwa Ali1 and Ghada Mohamed1 | ||||
| 1 Medical Biochemistry and Molecular Biology Department, 2 Pulmonary Medicine Department, Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine –Ain Shams University | ||||
| Abstract | ||||
| Background: Exosomes are microvesicles that are recently discovered in intercellular communication especially between tumor cells as lung cancer that are important for tumor development and progression. Objectives: Examine the diagnostic role of serum exosomal LncRNA in lung cancer among Egyptian population. Methods: Lung cancer characteristic exosomal RNA-based biomarker Lnc-RNA-RP11-510M2.10 was selected based on bioinformatic methods, followed by RT-qPCR validation of their expression in serum of 20 patients with lung cancer and 10 healthy volunteers. Results: serum exosomal Lnc-RNA-RP11-510M2.10 showed a significant negative association with lung cancer patients in comparison to patients with healthy persons (p<0.001). Conclusion: Lnc-RNA-RP11-510M2.10 could be used as diagnostic and prognostic biomarker tools for lung cancer. | ||||
| Keywords | ||||
| Lung Cancer; Exosomal RNA extraction; Lnc-RNA-RP11-510M2.10 | ||||
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