Low Dose Ketamine in Prevention of Propofol Injection Pain | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 25, Volume 72, Issue 3, July 2018, Page 4189-4193 PDF (258.6 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.9137 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Naglaa Mohammad Aly1; Manal Mohamed Kamal1; Dalia Ahmed Ibrahim1; Alaa Ahmed Whied Mohamed  2
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| 1Department of Anesthesia, Intensive Care &Pain Management, Faculty of Medicine - Ain Shams University | ||||
| 2Department of Anesthesia, Intensive Care &Pain Management, Faculty of Medicine - Ain Shams University | ||||
| Abstract | ||||
| Background: Propofol is the most widely used intravenous anesthetic agent for induction and maintenance of anesthesia as well as for sedation inside and outside operation theatre. Propofol is almost an ideal intravenous (IV) anesthetic agent, but pain on its injection still remain a problem. Pain may not be a serious complication, but most patients remember it as one of the unpleasant encounters with anesthetists. In one survey pain on propofol injection stands seventh most important problem in the current practice of clinical anesthesia. Ketamine is (NMDA) receptor antagonist agent and a dissociative anesthetic with neurostimulatory side effect, multiple research trials suggest ketamine as a strong analgesic agent in sub anesthetic IV doses. Objective: The aim of the current study was to prove the effectiveness of low dose ketamine in preventing propofol injection pain. Methodology: Two groups each included 60 patients (middle age females who performed ovum pick up surgery: Ketamine group 60 patient received ketamine 0.2 mg/kg with propofol. Saline group 60 patient received normal saline 10 ml with propofol. Results: In the current study pain and hemodynamic changes (BP, pulse) were observed. Regarding pain: The incidence of propofol injection pain in the current study was reduced from 93.2% in saline group to 55% in ketamine group, the incidence of severe pain was completely abolished with ketamine. Regarding hemodynamics: There was no statistical significance between both groups regarding heart rate, regarding BP the degree of drop in BP in ketamine group was to less extent than in saline group that proves the role of ketamine in hemodynamic stability. Conclusion: Finally ketamine in low dose was effective in reduction of propofol injection pain. | ||||
| Keywords | ||||
| propofol; Intravenous – Blood pressure; N-methyl-D asparate | ||||
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