Corn Silk Extract attenuates Acetaminophen-induced Hepatotoxicity in Rats | ||||
Damanhour Journal of Veterinary Sciences | ||||
Article 3, Volume 4, Issue 1, April 2020, Page 11-14 PDF (329.17 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/djvs.2020.30024.1015 | ||||
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Authors | ||||
Enas Wans 1; Mohamed Ahmed1; Ahmed Mousa1; Enas Tahoon2; Sahar Orabi 1 | ||||
1Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat city, Egypt. | ||||
2Department of Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt | ||||
Abstract | ||||
Paracetamol (acetaminophen-N-acetyl-p-aminophenol, PCM), a most common antipyretic & analgesic compound is widely used for the treatment of cold, cough, fever, pain including chronic pain, muscular ache, migraine, menstrual cramps, headache, backache and toothache. Acetaminophen over dosage is considered as one of the major causes of hepatic toxicity. The current study aimed to investigate the protective effect of corn silk methanolic extract (CSME) against acetaminophen (APAP)-induced hepatic toxicity. Therefore, the present study was carried out on 40 male Wistar albino rats, which were randomly allocated into four groups (n=10). Control group; orally administered with 0.9% normal saline. CSME group, orally received CSME, 400 mg/kg BW daily for 5 weeks; APAP group , orally administered with a single dose of APAP, 2g/kg BW; APAP+ CSME group , orally administered with CSME as in CSME group, followed by a single oral dose of APAP as in APAP group. The results of this study revealed that APAP caused a significant elevation in alanine transaminase (ALT) and aspartate transaminase (AST) activities. Also, APAP caused significant increases in of malondialdehyde (MDA) and nitric oxide (NO) concentrations compared with control group. However, pre-treatment with CSME restored all biochemical parameters toward the normal levels as the control group. In conclusion, oral administration of CSME protected rats against APAP hepatic toxicity through its antioxidant protective mechanisms. | ||||
Keywords | ||||
Acetaminophen; Hepatic toxicity; Corn silk; Malondialdehyde | ||||
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