Assessment of Interleukin (8) in Type 2 Diabetes Mellitus | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 29, Volume 72, Issue 4, July 2018, Page 4403-4406 PDF (158.25 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.9298 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ihab Nehad Farhan Mohammed  ; Ilham Aly Motawa; Mekky Abd El Monem Aly; Mahmoud Mohammed Mohammed Metwally,
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| Department of Clinical Pathology, Al-Hussein University Hospital, Al-Azhar Faculty of Medicine | ||||
| Abstract | ||||
| Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long- term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Type 2 diabetes (T2D) is characterized by a condition of systemic low-grade inflammation. IL-8 is an important member of the chemokine family of proinflammatory chemotactic cytokines. IL-8 was initially characterized as a potent chemoattractant of neutrophils and was later shown to also activate neutrophils. IL-8 is also known to be a potent promoter of angiogenesis. Objective: It was the Assessment of Interleukin (8) in Type 2 Diabetes Mellitus. Patients and Methods: Serum IL 8 level in Type 2 Diabetes Mellitus. 30 patients compared to 30 normal individuals were included in this study. Results: There was a highly statistical significant difference between all patients and control groups as regard serum IL 8 level (mean of serum IL 8 in patients and control groups were 69.9 ± 20.5 and 5.4 ± 3.3 respectively, p= < 0.001). Conclusion: Type 2 diabetes mellitus patients showed marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory state and metabolic control and therefore it may be used as a marker for the rate of development of diabeteic complications. | ||||
| Keywords | ||||
| Type 2 diabetes mellitus; Interleukin-8; CXC chemokine | ||||
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