Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia
El-hassab, M., Rashed, R., Elghannam, M., Megahed, A. (2020). Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia. EKB Journal Management System, 2(3), 528-534. doi: 10.21608/ijma.2020.22342.1081
Marwa Samir El-hassab; Rashed Mohamed Rashed; Magdy Zaky Elghannam; Alaa Eldin Mahmoud Megahed. "Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia". EKB Journal Management System, 2, 3, 2020, 528-534. doi: 10.21608/ijma.2020.22342.1081
El-hassab, M., Rashed, R., Elghannam, M., Megahed, A. (2020). 'Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia', EKB Journal Management System, 2(3), pp. 528-534. doi: 10.21608/ijma.2020.22342.1081
El-hassab, M., Rashed, R., Elghannam, M., Megahed, A. Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia. EKB Journal Management System, 2020; 2(3): 528-534. doi: 10.21608/ijma.2020.22342.1081

Predictive Value of both Serum Placental Protein-13 Level and Uterine Artery Doppler for Prediction of Pre-Eclampsia

International Journal of Medical Arts
Article 6, Volume 2, Issue 3, July 2020, Page 528-534  XML PDF (319.23 K)
Document Type: Original Article
DOI: 10.21608/ijma.2020.22342.1081
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Authors
Marwa Samir El-hassab email orcid 1; Rashed Mohamed Rashed2; Magdy Zaky Elghannam3; Alaa Eldin Mahmoud Megahed2
1Department of Obstetrics and Gynecology, Sammanoud General Hospital, Ministry of Health, Egypt.
2Department of Obstetrics and Gynecology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
3Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Abstract
Background: Preeclampsia [PE] is one of the commonest medical emergencies. It had high morbidity for the mother and her infant. Early diagnosis could reduce such morbidity. 
Aim of the work: To evaluate the role of maternal serum placental protein [PP13] levels and uterine artery Doppler in early prediction and prognosis of preeclampsia.
Patients and Methods: The study included 60 pregnant women in their first and early second trimester with high risk for preeclampsia. Patients were divided into three groups: control, mild and sever preeclampsia. All were subjected to proper history taking, clinical and obstetrical examination, laboratory investigations and ultrasound examination.
Results: Cesarean delivery was significantly increased in preeclampsia compared to controls [55% of mild and 20% of severe disease compared to 15% of controls]. Both uterine artery resistance index [RI] and pulsatility index [PI] were significantly increased in PE when compared to control and in severe when compared to mild PE groups. Finally, PP13 was significantly decreased in patients with severe PE [171.7±35.9] when compared to mild PE [213.1±41.8] or control group [254.8±51.1]. In addition, there was significant decrease in cases with mild PE when compared to control group. Finally, there was inverse [negative], moderate and statistically significant correlation between PP-13 from one side and each of systolic BP, diastolic BP, uterine artery RI and PI. In addition, both RI and PI were proportionally correlated with PI and RI.
Conclusion: The present study showed that PP13 combined with PI or RI can predict PE with a good sensitivity and specificity. 
Keywords
Preeclampsia; Placental Protein-13; Uterine Artery; Doppler; Prediction
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