EVALUATION OF CYCLODEXTRIN (SUGAMMADEX) FOR REVERSAL OF INTENSE NEUROMUSCULAR BLOCK OF ROCURONIUM AND VECURONIUM, EXPERIMENTAL AND CLINICAL STUDIES | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 15, Volume 43, Issue 3, December 2013, Page 705-714 PDF (251.16 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2013.93317 | ||||
View on SCiNiTO | ||||
Author | ||||
HATEM M. NASR ALKENANY | ||||
Department of Anesthesia and ICU, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt. | ||||
Abstract | ||||
This study evaluated and explored time course, efficacy, relation, safety, changes in heart rate, and blood pressure after a bolus dose of sugammadex or neostigmine for reversal of a prolonged rocuronium and vecuronium induced neuromuscular block. A total of 60 patients of both sexes, ‘ASA’ grade I, II and all were scheduled for elective surgery of 30-45 minutes duration. Informed oral consent was obtained from all patients to participate in this study. The results showed statistically significant progressive decrease of heart rate and blood pressure at 2, 5 and 10 minutes when compared to their basal values before anesthesia, then it starts to gain its normal value at 5 and 10 minutes, regardless the dose of sugammadex (effect of anesthesia). Also, heart rate and blood pressure showed statistically non-significant variance between groups of sugammadex when compared at any time of the study with the neostigmine groups (i.e. no effect of the dose on heart rate). | ||||
Keywords | ||||
Cyclodextrin; Rocuronium; Vecuronium; In-vitro; In-vivo studies | ||||
Statistics Article View: 98 PDF Download: 160 |
||||