Spectrophotometric Determination of Paracetamol using a Newly Synthesized Chromogenic Reagent 4-[(2-amino-1, 3thiazol-4-yl)amino]nitro benzene | ||||
| Egyptian Journal of Chemistry | ||||
| Article 2, Volume 63, Issue 12, December 2020, Page 4681-4693 PDF (1.86 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.17136.2053 | ||||
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| Authors | ||||
Ruba F. Abbas   1; Amjad G Allawi2; Nagham M Abdulhassan2; Nawal H Mahmoud3
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| 1Department of Chemistry, College of Science-University of AL-Mustansiriyah- Baghdad-Iraq | ||||
| 2chemistry department, collage of science, al mustansiriyah university | ||||
| 3chemistry department, collage of science, al mustansiriyah unversity | ||||
| Abstract | ||||
| This study describes the new simple and accurate spectrophotometric method for the determination of paracetamol after the formation of azo dye with a new chromogenic reagent 4 [(2-amino-1,3thiazol-4-yl)amino] nitrobenzene to form an orange-coloured product measured at 425 nm. The molecular structure of the newly synthesized compound was confirmed by several spectroscopic techniques such as UV-visible, FTIR, 1HNMR, and mass spectroscopy. Newly synthesized compound was in vitro screened against several bacterial species. The experimental conditions that affect the reaction were carefully optimized and under the optimized conditions, a linear relationship was obtained in the concentration range of 5–25mg.L−1 of paracetamol. A reaction with a new chromogenic reagent has been occurred at a stoichiometric ratio of 1:1. This method has a limit of detection of 1.334 mg.L-1 and Sandell's sensitivity of 0.0235 mg.cm-1 for new azo dye product. | ||||
| Keywords | ||||
| Paracetamol; Azo dye; Antibacterial activity; Thiazol; IHNMR; Spectrophotometric | ||||
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