Synthesis Biological Studies of Some New Heterocyclic Compound Derived From 2-Chloro-3-Formyl Quinoline And 4-(Benzyl Sulfonyl) Acetophenone | ||||
| Egyptian Journal of Chemistry | ||||
| Article 10, Volume 63, Issue 12, December 2020, Page 4769-4776 PDF (1.18 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2020.26354.2535 | ||||
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| Authors | ||||
Mohanad Saleh   1; Ala I Ayoub2; Ali O. Hammady3
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| 1Department of Chemistry, College of Education for pure science, University of Mosul | ||||
| 2Department of Renewable Energies , college of Sciences, University of Mosul | ||||
| 3Remote sensing and Gls , college of Sciences, University of Baghdad | ||||
| Abstract | ||||
| A new series of quinoline chalcones have been prepared from condensations of 2-chloro-3-formyl quinoline (1) with 4-(benzothio) acetophenone(2) and 4-(benzyl sulfonyl) acetophenone(3). The reaction of chalcones(4,5) with bromine gives dibromide(6,7). New pyrazoline derivatives were synthesized by condensation of chalcones (4 or 5) with hydrazine hydrate to give (8,9) and with hydrazine hydrate in glacial acetic acid(gla) to give (10,11) and with phenyl hydrazine to give (12,13). The prepared chalcones (4,5) and dibromide(6,7) and pyrazoline derivative (8-13)have been screened for anti-bacterial activities against two gram positive staphylococcus aureus and staphylococcus epidermidis and two gram negative Escherichia coli and Proteus vulgaris. The synthesized compounds are proven by IR & NMR spectral and physical method. | ||||
| Keywords | ||||
| 2-chloro-3-formyl quinoline; Chalcones; Dibromide; 4-(benzyl sulfonyl) acetophenone; 4-(benzothio) acetophenone | ||||
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