COMPARATIVE STUDY BETWEEN THE EFFECT OF NITAZOXANIDE AND PAROMOMYCINE IN TREATMENT OF CRYPTOSPORIDIOSIS IN HOSPITALIZED CHILDREN | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 18, Volume 43, Issue 2, August 2013, Page 463-470 PDF (228.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2013.94828 | ||||
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| Authors | ||||
| SALAH M. M. HUSSIEN1; OSAMA H. ABDELLA2; ANWAR H. ABUHASHIM3; GAMAL A. ABOSHIESHA3; MOHAMAD A. A. TAHA4; AHMED S. EL-SHEMY5; MOHAMAD M. EL-BADER6 | ||||
| 1Department of Parasitology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt. | ||||
| 2Department of Parasitology, FacultY of Medicine, Qena University, Egypt. | ||||
| 3Department of Parasitology, FacultY of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| 4Department of Parasitology, FacultY of Medicine, Al-Azhar University, Assuit, Egypt. | ||||
| 5Department of Pediatric, FacultY of Medicine, Al-Azhar University, Assuit, Egypt. | ||||
| 6Department of Pharmacology, Faculty of Medicine, Assuit University, Egypt. | ||||
| Abstract | ||||
| Ninety children infected with Cryptosporidium parvum attending Al-Azhar University Teaching Hospital (Assuit) were chosen (60 males & 30 females) with age range from 6 months to ten years. The patients were divided into two groups of 45 patients for each (G1 & G2). All patients suffered from chronic diarrhea for more than fifteen days. Cross-matched 45 children suffering from chronic diarrhea were used as a control group (G3). Stool samples were collected and examined for detection of Cryptosporidium oocysts using Sheather's sugar and Modified Ziehl- Nelseen stain techniques. The first group (G1) received Nitazoxanide (100 mg and 200 mg every 12 hours for 3 days for children aged 6 months to 3 years and children aged 4 to 10 years respectively), G2 received Paromomycin (25mg/kg/day for 2 weeks). Third group received placebo. Significant improvement and shortening of the duration of diarrhea occur in G1; of 45 patients received Nitazoxanide 39 cases showed complete clinical and laboratory cure (86.6 %), 5 cases showed clinical improvement with reduction in the number of oocysts and 1 case showed no cure. In G2 of 45 cases received Paromomycin 31 cases showed complete cure (68.8 %), 8 cases showed clinical improvement with reduction of oocysts number and 6 cases were not cured. Nitazoxanide proved highly effective than Paromomycin in cryptosporidiosis. | ||||
| Keywords | ||||
| Cryptosporidiuosis; Marasmus; Kwashiorkor; Nitazoxanide; Paromomycin | ||||
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