Liver Involvement in COVID-19 infected patients
Abd el rhman, M., Shafik, N., Maher, A., Hemdan, S., Abd Elhamid, R. (2020). Liver Involvement in COVID-19 infected patients. EKB Journal Management System, 24(2), 15-19. doi: 10.21608/smj.2020.27882.1142
Mona Mohammed Abd el rhman; Noha Saber Shafik; Amira Maher; Shimaa Badawy Hemdan; Reem Mahmoud Abd Elhamid. "Liver Involvement in COVID-19 infected patients". EKB Journal Management System, 24, 2, 2020, 15-19. doi: 10.21608/smj.2020.27882.1142
Abd el rhman, M., Shafik, N., Maher, A., Hemdan, S., Abd Elhamid, R. (2020). 'Liver Involvement in COVID-19 infected patients', EKB Journal Management System, 24(2), pp. 15-19. doi: 10.21608/smj.2020.27882.1142
Abd el rhman, M., Shafik, N., Maher, A., Hemdan, S., Abd Elhamid, R. Liver Involvement in COVID-19 infected patients. EKB Journal Management System, 2020; 24(2): 15-19. doi: 10.21608/smj.2020.27882.1142

Liver Involvement in COVID-19 infected patients

Sohag Medical Journal
Article 3, Volume 24, Issue 2, April 2020, Page 15-19  XML PDF (782.22 K)
Document Type: Original Article
DOI: 10.21608/smj.2020.27882.1142
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Authors
Mona Mohammed Abd el rhman email 1; Noha Saber Shafik2; Amira Maher3; Shimaa Badawy Hemdan4; Reem Mahmoud Abd Elhamid5
1tropical medicine and gastroentrology, faculty of medicine, sohag university
2Medical microbiology , Faculty of Medicine, Sohag University, Egypt
3Tropical medicine and gastroenterology, faculty of medicine, sohag university, sohag, egypt
4Lecturer at Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University
5Department of Tropical Medicine & Gastroenterology, Sohag Faculty of Medicine, Sohag University
Abstract
Coronavirus outbreak in December 2019 was reported in the city of Wuhan, China firstly named 2019 novel coronavirus (2019-nCoV). Later on, the World Health Organization (WHO) declared another name for this disease which is Corona Virus Disease (COVID-19). On the eleventh of March, 2020, WHO considered the disease as a pandemic. Person-to-person transmission has been reported either through droplet transmission or direct contact. The affected individuals complain from mild symptoms to severe acute respiratory syndrome (ARDS).
With the increasing number of COVID-19 infected patients, several studies reported that the liver is the most frequently affected organ after lung damage. Elevation of transaminases was frequently reported in patients with severe disease and patients admitted to ICU. The mechanism of hepatic injury in COVID-19 not completely understood. Multiple factors have been accused including direct invasion of the hepatocyte by SARS-CoV-2, high level of inflammatory mediators, drug-induced hepatic injury, and or concomitant chronic liver diseases. So, evaluation of the mechanism of hepatic injuries in COVID-19 infection is needed.
Keywords
SARS-CoV-2; Transaminases; Mechanisms of liver injury
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