ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT
MÉNDEZ-SAMPERIO, P., de-la-ROSA-ARANA, J. (2013). ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT. EKB Journal Management System, 43(1), 195-208. doi: 10.21608/jesp.2013.94860
P. MÉNDEZ-SAMPERIO; J. L. de-la-ROSA-ARANA. "ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT". EKB Journal Management System, 43, 1, 2013, 195-208. doi: 10.21608/jesp.2013.94860
MÉNDEZ-SAMPERIO, P., de-la-ROSA-ARANA, J. (2013). 'ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT', EKB Journal Management System, 43(1), pp. 195-208. doi: 10.21608/jesp.2013.94860
MÉNDEZ-SAMPERIO, P., de-la-ROSA-ARANA, J. ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT. EKB Journal Management System, 2013; 43(1): 195-208. doi: 10.21608/jesp.2013.94860

ANTIMICROBIAL PEPTIDES AS PARASITICIDAL AGAINST HUMAN TRYPANOSOMATIDS: MECHANISMS OF ACTION AND CURRENT STATUS IN DEVELOPMENT

Journal of the Egyptian Society of Parasitology
Article 16, Volume 43, Issue 1, April 2013, Page 195-208  XML PDF (283.3 K)
Document Type: Original Article
DOI: 10.21608/jesp.2013.94860
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Authors
P. MÉNDEZ-SAMPERIO1; J. L. de-la-ROSA-ARANA2
1Departamento de Inmunología1, Escuela Nacional de Ciencias Biológicas, IPN. Prol. Carpio y Plan de Ayala, México, D.F. 11340,
2Laboratorio de Helmintos Tisulares, Instituto de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, Carpio 470, Santo Tomás, Miguel Hidalgo, México D.F. 11340.
Abstract
Trypanosomes cause a variety of tropical diseases that affect the livelihood of individuals worldwide. The currently used pharmaceutical treatments rely on chemotherapy. However, many of these drugs are very expensive, and highly toxic.
In addition, parasite resistance to several of the therapeutic drugs used is increasing. Therefore, there is a growing need for new control measures for many of these diseases. One new approach is the use of antimicrobial peptides (AMPs) to disease control, since these peptides can be used as potential anti-parasite effector molecules. This review summarizes and discusses the parasiticidal properties of AMPs for treating trypanosome infections, highlighting their mechanisms of action and current status in development.
Keywords
Antimicrobial peptides; Leishmania; Trypanosoma; human infection
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