Assessment of Vitamin D Status In Patients With Essential Hypertension | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 5, Volume 72, Issue 5, July 2018, Page 4434-4438 PDF (183.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2018.9496 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sameh Ahmad Abd-El Kader  1; Youssef Khalel Ahmad1; Esam Mohamed El-Ghamry1; Salwa Tawfik2; Wael Mohamed Atia3; Mohammad Mohammad Keder4
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| 1Internal Medicine Department | ||||
| 2Internal Medicine, National Research Center | ||||
| 3Cardiology Department | ||||
| 4Clinical Pathology Department, Faculty of Medicine, Al-Azhar University | ||||
| Abstract | ||||
| Background: There is close relationship between Vit D deficiency and hypertension. It was found that Vit D is potent inhibitor of Renin Aldosterone Angiotensin System (RAAS) which is the main mechanism responsible for development of hypertension. Aim of The Work: To assess the role of vitamin D deficiency in the development of essential hypertension and aggravation of its vascular complications. Subjects and Methods: This study was conducted on 80 individuals. Individuals were divided into two groups: Group 1: comprising 60 patients with essential hypertension. Group 2: comprising 20 healthy individuals. All individuals included in the study were submitted to: Complete history and physical examinations to evaluate exclusion criteria. Liver and renal function tests, fasting and PP blood glucose, CBC, lipid profile, serum vitamin D (25hydroxycholecalciferol), serum Ca & Ph. Doppler study on carotid artery to assess vascular complications and Echocardiography to assess ventricular mass was done. Results: There was statistically significant decrease (p value <0.05) in vitamin D in patients group in comparison to control group. There was highly statistically significant increase (p value <0.001) in intimal thickness and left ventricular mass in patients with low vitamin D level in comparison to patients with normal vitamin D level. In the patient group, 6 patients (10%) were suffering from vitamin D deficiency while 30 (50%) were suffered from vitamin D insufficiency while 24 (35%) show normal levels of vitamin D. Interestingly, intimal thickness and ventricular mass were significantly higher in patients with essential hypertension with low vitamin D than those with normal vitamin D levels. Conclusions: Vitamin D deficiency occurs in the majority of essential hypertension patients and therefore decreased serum vitamin D levels is considered an additional risk factor for cardiovascular morbidity and mortality. | ||||
| Keywords | ||||
| Vitamin D Status; Essential hypertension | ||||
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