THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS
Amin, N., Abdel Ghany, S., Hegazi, R. (2016). THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS. EKB Journal Management System, 62(Issue 1 - January (Part 3)), 765-775. doi: 10.21608/edj.2016.95106
Nermine Raouf Amin; Safa Fathy Abdel Ghany; Radwa Hamed Hegazi. "THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS". EKB Journal Management System, 62, Issue 1 - January (Part 3), 2016, 765-775. doi: 10.21608/edj.2016.95106
Amin, N., Abdel Ghany, S., Hegazi, R. (2016). 'THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS', EKB Journal Management System, 62(Issue 1 - January (Part 3)), pp. 765-775. doi: 10.21608/edj.2016.95106
Amin, N., Abdel Ghany, S., Hegazi, R. THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS. EKB Journal Management System, 2016; 62(Issue 1 - January (Part 3)): 765-775. doi: 10.21608/edj.2016.95106

THE EFFECT OF OXIDATIVE STRESS ON MITOCHONDRIAL ULTRASTRUCTURE AND IMMUNOEXPRESSION OF ERK-1 AND HIF-1 ALPHA IN ORAL EPITHELIAL DYSPLASIA INDUCED IN EXPERIMENTAL ANIMALS

Egyptian Dental Journal
Article 22, Volume 62, Issue 1 - January (Part 3), January 2016, Page 765-775  XML PDF (2.62 MB)
Document Type: Original Article
DOI: 10.21608/edj.2016.95106
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Authors
Nermine Raouf Amin1; Safa Fathy Abdel Ghany2; Radwa Hamed Hegazi3
1Lecturer of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University
2Assistant Professor of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University
3Assistant Professor of Oral Biology, Faculty of Oral and Dental Medicine, Cairo University
Abstract
Background: Oxidative stress and accumulation of reactive oxygen species may play a role in the pathogenesis of cancer. They were reported in precancerous and cancerous cells.
 
Methods: An animal model of carcinogenesis was used to detect the effect of oxidative stress on mitochondrial ultrastructure by transmission electron microscope and the levels of extracellular signal- regulated kinase-1(ERK-1) and hypoxia inducible factor-1 alpha (HIF-1α) by immunohistochemistry in mild and severe oral epithelial dysplasia (OED) induced in tongues of experimental mice.
 
Results: We identified degeneration and enlargement of mitochondria in association with up- regulation of both ERK-1 and HIF-1α from normal control to mild OED and reached their highest values in severe OED.
 
Conclusions: Degeneration and enlargement of mitochondria in association with up-regulation of both ERK-1 and HIF-1α can be indicative features of dysplastic changes and may act as early markers for malignancy.
 
Keywords
Oral epithelial dysplasia; oxidative stress; extracellular signal-regulated kinase -1 (ERK-1); hypoxia inducible factor-1 alpha (HIF-1α)
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