Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period
Abou-Bakr, D., Mansour, R. (2020). Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period. EKB Journal Management System, 40(2), 54-69. doi: 10.21608/besps.2020.21680.1040
Doaa Ahmed Abou-Bakr; Rania Salah Al sayed eissa Mansour. "Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period". EKB Journal Management System, 40, 2, 2020, 54-69. doi: 10.21608/besps.2020.21680.1040
Abou-Bakr, D., Mansour, R. (2020). 'Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period', EKB Journal Management System, 40(2), pp. 54-69. doi: 10.21608/besps.2020.21680.1040
Abou-Bakr, D., Mansour, R. Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period. EKB Journal Management System, 2020; 40(2): 54-69. doi: 10.21608/besps.2020.21680.1040

Maternal Metabolic Alterations in Monosodium Glutamate Fed Rats during Gestation and Lactation Period

Bulletin of Egyptian Society for Physiological Sciences
Article 5, Volume 40, Issue 2, June 2020, Page 54-69  XML PDF (696.92 K)
Document Type: Original Article
DOI: 10.21608/besps.2020.21680.1040
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Authors
Doaa Ahmed Abou-Bakr email orcid 1; Rania Salah Al sayed eissa Mansourorcid 2
1Physiology department, Faculty of medicine, Ain shams university, Cairo, Egypte
2Physiology department, Faculty of medicine, Ain shams university, Cairo, Egypt
Abstract
Background: Monosodium glutamate (MSG), an extensively used food additive, is claimed to cause many health problems, its use is still under debate.
Aim: to explore the metabolic and hypertensive effect of MSG dietary administration in pregnant and lactating female rats, and its possible underlying mechanism.
Methods: 16 adult female albino Wister rats were divided into 2 groups, control group; were fed standard rat chow, and MSG group; were fed 2% MSG supplemented rat chow throughout gestation and lactation period. Oral glucose tolerance test (OGTT) and arterial blood pressure (ABP) were measured at mid and late gestation, mid and late lactation periods. At mid lactation period, a retroorbital samples were analyzed for fasting glucose, lipid profile; triglycerides (TGs), total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C), hormonal assays; insulin, glucagon, prolactin, corticosterone and ACTH, as well as pancreatic lipase, amylase and malondialdehyde (MDA). By the end of lactation, adipose tissue was assessed for glucose transporter-4 (GLUT-4) and hormone sensitive lipase (HSL) relative expression.
Results: MSG rats showed elevated ABP during pregnancy and lactation, with impaired OGTT at mid and late lactation period. Fasting serum glucose, TGs, TC, LDL-C, glucagon, corticosterone, pancreatic lipase and amylase, MDA as well as adipose tissue HSL expression were significantly elevated, while, fasting serum insulin, ACTH and adipose tissue GLUT-4 expression were significantly declined in MSG fed rats as compared to control group.
Conclusion: MSG feeding during pregnancy and lactation induced hypertension and metabolic alterations that could be due to pancreatic and adrenal affection secondary oxidative stress.
Keywords
MSG; pregnancy; lactation; metabolism; pancreatic function
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