Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.
El Agamy, D., Ahmed, F., Elfiky, S. (2020). Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.. EKB Journal Management System, 40(2), 113-125. doi: 10.21608/besps.2020.23788.1045
Dalia Fathy El Agamy; Fatma El Desouky Ahmed; Safa Riyad Elfiky. "Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.". EKB Journal Management System, 40, 2, 2020, 113-125. doi: 10.21608/besps.2020.23788.1045
El Agamy, D., Ahmed, F., Elfiky, S. (2020). 'Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.', EKB Journal Management System, 40(2), pp. 113-125. doi: 10.21608/besps.2020.23788.1045
El Agamy, D., Ahmed, F., Elfiky, S. Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.. EKB Journal Management System, 2020; 40(2): 113-125. doi: 10.21608/besps.2020.23788.1045

Intermittent Calorie Restriction Ameliorates Behavioral Changes and Tau Hyperphosphorylation in Chronic Immobilization Stress in Rats.

Bulletin of Egyptian Society for Physiological Sciences
Article 9, Volume 40, Issue 2, June 2020, Page 113-125  XML PDF (582.28 K)
Document Type: Original Article
DOI: 10.21608/besps.2020.23788.1045
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Authors
Dalia Fathy El Agamy email orcid 1; Fatma El Desouky Ahmed2; Safa Riyad Elfiky2
1Physiology Department, Faculty of Medicine, Menoufia University, Egypt
2Clinical Pharmacology Department, Faculty of Medicine, Menoufia University, Egypt
Abstract
Background: Chronic stress has been linked to mood and anxiety disorders and alteration of cognitive functions, such as memory. Intermittent calorie restriction (ICR) is a repeated mild stress that enhances the cell ability to combat more severe stress.
Aim: Examination of the effects of ICR on rat behaviour and Tau hyperphosphorylation in chronic immobilization stress (CIS) rat model.
Methods: 32 rats were divided into 4 equal groups: control, ICR (subjected to ICR protocol), CIS (subjected to CIS protocol), and CIS+ICR (subjected to both CIS and ICR protocols). After performing behavioural (open field and Barnes maze) tests, serum level of corticosterone, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined, and hippocampal tissue level of phosphorylated Tau (phospho-Tau), noradrenaline, and serotonin were measured.
Results: We found that, ICR significantly altered the stress-induced anxiety-like behavior and memory disturbances (P<0.001). Rats exposed to both ICR and CIS protocols had significantly lower levels of phospho-Tau, corticosterone, and TNF-α, and enhanced levels of noradrenaline and serotonin than those subjected to CIS alone (P<0.01).
Conclusion: our results suggest that ICR protects against chronic stress-induced anxiety-like behaviour, memory disturbance and Tau hyperphosphorylation, possibly through inhibition of hypothalamic pituitary adrenal (HPA) axis, anti-inflammatory effects, and enhancement of noradrenaline and serotonin hormones.
Keywords
calorie restriction; locomotor activity; stress; tau proteins
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