Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient
Elghareib, M., Fouda, I., Khodair, H., Al-Adl, A. (2020). Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient. EKB Journal Management System, 2(3), 655-660. doi: 10.21608/ijma.2020.31065.1127
Mohamed Fathy Elghareib; Ibrahim Fouda; Hassan Khodair; Ahmed Salama Al-Adl. "Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient". EKB Journal Management System, 2, 3, 2020, 655-660. doi: 10.21608/ijma.2020.31065.1127
Elghareib, M., Fouda, I., Khodair, H., Al-Adl, A. (2020). 'Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient', EKB Journal Management System, 2(3), pp. 655-660. doi: 10.21608/ijma.2020.31065.1127
Elghareib, M., Fouda, I., Khodair, H., Al-Adl, A. Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient. EKB Journal Management System, 2020; 2(3): 655-660. doi: 10.21608/ijma.2020.31065.1127

Comparative Study between Sertraline and Omega-3 Supplementation in The Treatment of Uremic Pruritus in Hemodialysis Patient

International Journal of Medical Arts
Article 25, Volume 2, Issue 3, July 2020, Page 655-660  XML PDF (260.97 K)
Document Type: Original Article
DOI: 10.21608/ijma.2020.31065.1127
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Authors
Mohamed Fathy Elghareib email 1; Ibrahim Fouda1; Hassan Khodair1; Ahmed Salama Al-Adl2
1Department of Dermatology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
2Department of Internal Medicine, Damietta Faculty of Medicine, Al-Azhar University, Egypt.
Abstract
Background: Pruritus in uremic patients decreases the quality of life because of sleep disturbances, depression and anxiety, thus, pruritus remains an important health issue in ESRD patients. 
Aim of the work:To evaluate the efficacy and safety of sertraline versus omega 3 supplementation in the treatment of uremic pruritus.
Patients and Methods:This randomized case control study was conducted on patients with ESRD patients .All studied subjects had been collected from the Al-Azhar hospital [Damietta] Dialysis Center. This study had been carried out on 50 patients divided into: Group [A] : consists of 25patients had been received 50 mg sertraline twice a day for 8 weeks. Group [B]: consists of 25 patients and had been receive 3 gm omega-3 daily.
Results: Although pruritus severity decrease significantly in both groups and both scoring systems [P<0.001], the reduction was significantly more in sertraline group [p
Conclusion: Omega-3 fatty acids found to be effective in decreasing of uremic pruritus. So, it seems that Omega-3 fatty acids could be used as an efficient drug for treatment of pruritus in uremic patients. The present study showed that low-dose sertraline was effective for antihistamine-refractory uremic pruritus than omeg3 in renal palliative care patients.
Keywords
Omega-3; Sertraline; Pruritus; End-stage Renal Disease; Uremic; Renal
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