Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin
albahy, G., Abbas, Y., Hezma, A., Gweily, N. (2020). Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin. EKB Journal Management System, 17(2), 77-85. doi: 10.21608/jtcps.2020.32002.1041
gamal saeed albahy; Y. M. Abbas; A. M. Hezma; Noha Gweily. "Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin". EKB Journal Management System, 17, 2, 2020, 77-85. doi: 10.21608/jtcps.2020.32002.1041
albahy, G., Abbas, Y., Hezma, A., Gweily, N. (2020). 'Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin', EKB Journal Management System, 17(2), pp. 77-85. doi: 10.21608/jtcps.2020.32002.1041
albahy, G., Abbas, Y., Hezma, A., Gweily, N. Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin. EKB Journal Management System, 2020; 17(2): 77-85. doi: 10.21608/jtcps.2020.32002.1041

Preparation of Porous n-HAp Scaffold Enforced with MWCNTs as Vehicle for Local Drug Delivery of Ciprofloxacin

Journal of Textiles, Coloration and Polymer Science
Article 3, Volume 17, Issue 2, October 2020, Page 77-85  XML PDF (2.05 MB)
Document Type: Original Article
DOI: 10.21608/jtcps.2020.32002.1041
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Authors
gamal saeed albahy1; Y. M. Abbas2; A. M. Hezma3; Noha Gweily email orcid 4
1Spectroscopy Department, Physics Division, National Research Center (NRC)
2Physics Department, Suez Canal University, Ismailia, Egypt
3Spectroscopy Department, Physics Research Division, National Research Centre, Cairo 12622, Egypt
4Spectroscopy Department, National Research Centre, Egypt
Abstract
The main objective of this study was synthesis a composite of porous n-HAp/MWCNTs loaded with ciprofloxacin (CFX) as a local drug delivery during surgical procedures with sustained release behavior in the treatment of bone infection minimizing the risks of systemic toxicity. Ciprofloxacin is used as an antibacterial of the Gram-positive and Gram-negative bacteria that affect the bones. The prepared scaffolds loaded with ciprofloxacin were characterized by Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, Scanning Electron Microscope (SEM) and Cytotoxicity Testing. The in-vitro release of the drug of such scaffolds was also investigated as well as the study of the Entrapment efficiency of scaffold by using U.V spectroscopy. The cytotoxicity of hydroxyapatite containing MWCNTS applied on normal bone cells for the highest rate of 3 x 10-3 showed the cell viability greater than 90%. The CFX was successfully loaded within such HAp-nano Scaffolds referred to their reasonable encapsulation efficiencies which they revealed. The drug release behavior showed promising sustained prolonged profiles up to 8 days with minimum initial burst effects.
Keywords
Hydroxyapatite; MWCNTs; Ciprofloxacin; Cytotoxicity; Drug Delivery
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