Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study
Shafik, E., Mohareb, D., Hetta, H., khallaf, S., Abd el-Rady, N., Gaber, Z., Abu Rahma, M., Abbas, W., Atta, H. (2020). Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study. EKB Journal Management System, 4(2), 121-131. doi: 10.21608/jcbr.2020.28094.1029
Engy Shafik; Dina Ahmed Mohareb; Helal Hetta; Salah M khallaf; Nessren Abd el-Rady; Zainab Gaber; Mohamed Zakaria Abu Rahma; Wael A Abbas; Haisam Atta. "Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study". EKB Journal Management System, 4, 2, 2020, 121-131. doi: 10.21608/jcbr.2020.28094.1029
Shafik, E., Mohareb, D., Hetta, H., khallaf, S., Abd el-Rady, N., Gaber, Z., Abu Rahma, M., Abbas, W., Atta, H. (2020). 'Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study', EKB Journal Management System, 4(2), pp. 121-131. doi: 10.21608/jcbr.2020.28094.1029
Shafik, E., Mohareb, D., Hetta, H., khallaf, S., Abd el-Rady, N., Gaber, Z., Abu Rahma, M., Abbas, W., Atta, H. Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study. EKB Journal Management System, 2020; 4(2): 121-131. doi: 10.21608/jcbr.2020.28094.1029

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Egyptian Journal of Cancer and Biomedical Research
Article 6, Volume 4, Issue 2, August 2020, Page 121-131  XML PDF (3.81 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2020.28094.1029
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Authors
Engy Shafik1; Dina Ahmed Mohareb2; Helal Hetta3; Salah M khallaf4; Nessren Abd el-Rady5; Zainab Gaber6; Mohamed Zakaria Abu Rahma6; Wael A Abbas7; Haisam Atta email orcid 8
1Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
3Department of Medical Microbiology and Immunology, Faculty of Medicine, University, Assiut, Egypt
4Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut,Egypt.
5Department of Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
6Department of Tropical medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
7Department of Internal medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
8Department of Radiology, South Egypt Cancer Institute, Assiut University, Assiut,Egypt.
Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Keywords
Colorectal cancer; Fat analysis; Leptin; Resistin
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