EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION
ROZEIK, M., HAMMAM, O., ABD EL-SATTAR, H., EL-TIBY, D., EL-DESSOUKY, Y. (2013). EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION. EKB Journal Management System, 43(1), 235-244. doi: 10.21608/jesp.2013.96260
M. S. ROZEIK; O. A. HAMMAM; H. ABD EL-SATTAR; D. M. EL-TIBY; Y. M. M. EL-DESSOUKY. "EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION". EKB Journal Management System, 43, 1, 2013, 235-244. doi: 10.21608/jesp.2013.96260
ROZEIK, M., HAMMAM, O., ABD EL-SATTAR, H., EL-TIBY, D., EL-DESSOUKY, Y. (2013). 'EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION', EKB Journal Management System, 43(1), pp. 235-244. doi: 10.21608/jesp.2013.96260
ROZEIK, M., HAMMAM, O., ABD EL-SATTAR, H., EL-TIBY, D., EL-DESSOUKY, Y. EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION. EKB Journal Management System, 2013; 43(1): 235-244. doi: 10.21608/jesp.2013.96260

EXPRESSION OF FAS PROTEIN (CD95) AND FAS LIGAND IN LIVER TISSUE OF PATIENTS WITH HCV-INDUCED CHRONIC LIVER DISEASE AND ITS CORRELATION WITH THE DISEASE PROGRESSION

Journal of the Egyptian Society of Parasitology
Article 19, Volume 43, Issue 1, April 2013, Page 235-244  XML PDF (233.68 K)
Document Type: Original Article
DOI: 10.21608/jesp.2013.96260
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Authors
M. S. ROZEIK1; O. A. HAMMAM2; H. ABD EL-SATTAR1; D. M. EL-TIBY1; Y. M. M. EL-DESSOUKY1
1Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo, Egypt.
2Department of Pathology, Theodor Bilharz Research Institute, Imbaba P.O. Box 30, Giza, Egypt.
Abstract
This study evaluated hepatic expression of both Fas and Fas ligand (FasL) in patients with hepatitis c virus (HCV)-induced chronic liver disease and its correlation with the histopathological activity and laboratory parameters as an early predictor
of advancement of the disease. The selected patients were (39) males and (21) females, their ages ranged from
(20-67years) with a mean of 43.5±4.5 years, as well as (10) subjects (normal individuals) serving as a control group. They were (7) males and (3) females, their age ranged from (26-53 years) with a mean of 39.5±7.3 years. Patients were grouped as (1) Chronic hepatitis (CH) group including (30) patients with chronic viral hepatitis C. (2) Liver cirrhosis (LC) group including (30) patients with post hepatitis C cirrhosis. Liver biopsy was done for all subjects using an automated 18-gauge true cut needle. Sections were stained with Haematoxylin and Eosin for histopathological diagnosis and with Maisson and Trichrome for assessment of fibrosis. Unstained paraffin sections from each case were subjected for immuno-histochemical procedures using indirect immunoflourescence technique for detection of apoptotic hepatic and lymphocytic cells using monoclonal antibodies. Semiquantitative analysis of the pattern and distribution of the Fas antigen and Fas Ligand as indicators for hepatic apoptosis was studied and assessed.
Keywords
Egypt Fas; Fas ligand; apoptosis; HCV; chronic liver disease
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