BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE
ABDEL-GHANY, R., RABIA, I., EL-AHWANY, E., SABER, S., GAMAL, R., NAGY, F., MAHMOUD, O., HAMAD, R., BARAKAT, W. (2015). BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE. EKB Journal Management System, 45(3), 511-520. doi: 10.21608/jesp.2015.96281
RASHA ABDEL-GHANY; IBRAHIM RABIA; EMAN EL-AHWANY; SAMEH SABER; RASHA GAMAL; FATEN NAGY; OLAA MAHMOUD; RABAB SALEM HAMAD; WALEED BARAKAT. "BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE". EKB Journal Management System, 45, 3, 2015, 511-520. doi: 10.21608/jesp.2015.96281
ABDEL-GHANY, R., RABIA, I., EL-AHWANY, E., SABER, S., GAMAL, R., NAGY, F., MAHMOUD, O., HAMAD, R., BARAKAT, W. (2015). 'BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE', EKB Journal Management System, 45(3), pp. 511-520. doi: 10.21608/jesp.2015.96281
ABDEL-GHANY, R., RABIA, I., EL-AHWANY, E., SABER, S., GAMAL, R., NAGY, F., MAHMOUD, O., HAMAD, R., BARAKAT, W. BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE. EKB Journal Management System, 2015; 45(3): 511-520. doi: 10.21608/jesp.2015.96281

BLOCKADE OF PGE2, PGD2 RECEPTORS CONFERS PROTECTION AGAINST PREPATENT SCHISTOSOMIASIS MANSONI IN MICE

Journal of the Egyptian Society of Parasitology
Article 6, Volume 45, Issue 3, December 2015, Page 511-520  XML PDF (421.74 K)
Document Type: Original Article
DOI: 10.21608/jesp.2015.96281
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Authors
RASHA ABDEL-GHANY1; IBRAHIM RABIA2; EMAN EL-AHWANY3; SAMEH SABER1; RASHA GAMAL1; FATEN NAGY3; OLAA MAHMOUD4; RABAB SALEM HAMAD5, 6; WALEED BARAKAT1
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
2Department of Parasitology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.
3Department of Immunology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.
4Department of Haematology, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.
5Department of Central Laboratory, Theodor Bilharz Research Institute, P.O. Box 30 Imbaba, Giza, 12411, Egypt.+
6Department Biological Sciences, King Faisal University, P.O. Box 380, Hofouf 31982, Saudi Arabia.
Abstract
Schistosomiasis is a chronic disease with considerable social impact. Despite the availability of affordable chemotherapy, drug treatment has not significantly reduced the overall number of disease cases. Among other mechanisms, the parasite produces PGE2 and PGD2 to evade host immune defenses. To investigate the role of PGE2 and PGD2 in schistosomiasis, we evaluated the effects of L-161,982, Ah6809 (PGE2 receptor antagonists alone or combined with each other) and MK-0524 (PGD2 receptor antagonist) during prepatent Schistosoma mansoni infection. Drugs were administered intraperitoneally an hour before and 24 hours after infection of C57BL/6 mice with 100 Schistosoma mansoni cercariae. L-161,982, Ah6809, their combination and MK-0524 caused partial protection against pre-patent S. mansoni infection which was mediated by biasing the immune response towards Th1 phenotype. These results showed that blockade of PGE2 and PGD2 receptors confers partial protection against pre-patent S. mansoni infection in mice and that they may be useful as adjunctive therapy to current anti-schistosomal drugs or vaccines.
Keywords
Schistosoma mansoni; PGE2; PGD2; receptor; blocker
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