ANTIPARASITIC ACTIVITY OF SILVER AND COPPER OXIDE NANOPARTICLES AGAINST ENTAMOEBA HISTOLYTICA AND CRYPTOSPORIDIUM PARVUM CYSTS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 15, Volume 45, Issue 3, December 2015, Page 593-602 PDF (776.93 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2015.96308 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| ABDEL HALIM A. SAAD1; MOHAMED I. SOLIMAN1; AHMED M. AZZAM2; AMR B. MOSTAFA1 | ||||
| 1Department of Zoology, Faculty of Science, Ain-Shams University, Cairo 11566, Egypt. | ||||
| 2Department of Environmental Researches, Theodor Bilharz Research Institute, >Imbaba P.O. Box 30, Giza 12411, Egypt. | ||||
| Abstract | ||||
| Nanoparticles (NPs) have received more attention as antiparasitic agents. In the present study, silver and copper nanoparticles were synthesized and characterized using scanning electron microscopy (SEM), transmission electron microscope (TEM) and X-ray fluorescence (XRF). The antiparasitic activity of Ag and CuO nanoparticles were tested against two of the most environmentally spread parasites in Egypt (Entamoeba histolytica and Cryptosporidium parvum). The average sizes of synthesized Ag NPs and CuO NPs were 9 & 29 nm respectively and a significant reduction for cysts viability (p > 0.05) was observed for CuO NPs against E. histolytica cysts and Ag NPs against C. parvum oocysts. Moreover, LC50-3h of CuO NPs for E. histolytica and C. parvum were 0.13 and 0.72 mg/l, while Ag NPs recorded 0.34 and 0.54 mg/l respectively. Accordingly, these NPs could be suggested as a new nanoform agent for safe and effective treatment of E. histolytica and C. parvum parasites. | ||||
| Keywords | ||||
| Antiparasitic; silver; copper; nanoparticles; Entamoeba histolytica; Cryptosporidium parvum | ||||
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