SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.
Mahmoud, W., Abd-Elgawad, E., Mesallam, D., El-Serafy, T. (2022). SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.. EKB Journal Management System, 28(6.2), 326-332. doi: 10.21608/zumj.2020.30794.1859
Wael Mahmoud; Elhady Abd-Elgawad; Dalia Mesallam; Tamer El-Serafy. "SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.". EKB Journal Management System, 28, 6.2, 2022, 326-332. doi: 10.21608/zumj.2020.30794.1859
Mahmoud, W., Abd-Elgawad, E., Mesallam, D., El-Serafy, T. (2022). 'SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.', EKB Journal Management System, 28(6.2), pp. 326-332. doi: 10.21608/zumj.2020.30794.1859
Mahmoud, W., Abd-Elgawad, E., Mesallam, D., El-Serafy, T. SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.. EKB Journal Management System, 2022; 28(6.2): 326-332. doi: 10.21608/zumj.2020.30794.1859

SERUM MALONDIALDEHYDE AS A PREDICTOR OF POST-STROKE COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS.

Zagazig University Medical Journal
Article 42, Volume 28, Issue 6.2, November 2022, Page 326-332  XML PDF (363.05 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.30794.1859
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Authors
Wael Mahmoud1; Elhady Abd-Elgawad2; Dalia Mesallam email orcid 3; Tamer El-Serafy4
1Neurology department, faculty of Medicine Zagazig university
2Neurology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4neurology department, faculty of medicine, zagazig university
Abstract
Background: Cognitive impairment is a common consequence of stroke and is associated with poor functional outcome and higher risk of recurrent cerebrovascular stroke. Serum Malondialdehyde (MDA) is used as a biomarker to measure the oxidative stress. The association of serum MDA levels in acute ischemic stroke and post-stroke cognitive impairment (PSCI) is infrequently been studied.
Objective: This study aimed to identify the relationship between serum MDA levels in the first week after acute ischemic stroke, and PSCI after three months.
Methods: Thirty-seven patients 17 males (45.9%) and 20 females (54.1%) with acute ischemic stroke recruited from Neurology critical care units, Zagazig University hospitals were prospectively enrolled in follow-up cohort study. Serum MDA was measured within 24 h after admission. Cognitive outcome after three months was assessed by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
Results: 43.2% of patients had no cognitive impairment while 35.1%had mild and 21.6% had severe cognitive impairment according to MMSE and 59.5%had unfavorable MoCA outcomes. There was a significant negative correlation between serum MDA and MMSE and MoCA.
Conclusion: Increasing MDA serum level had a significant effect on development of PSCI.
Keywords
Ischemic Stroke; Malondialdehyde; Cognition
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