Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population
said, N., fekry, R., elmesallmy, H. (2022). Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population. EKB Journal Management System, 28(6.2), 333-338. doi: 10.21608/zumj.2020.31794.1871
noha said; reda fekry; hala elmesallmy. "Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population". EKB Journal Management System, 28, 6.2, 2022, 333-338. doi: 10.21608/zumj.2020.31794.1871
said, N., fekry, R., elmesallmy, H. (2022). 'Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population', EKB Journal Management System, 28(6.2), pp. 333-338. doi: 10.21608/zumj.2020.31794.1871
said, N., fekry, R., elmesallmy, H. Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population. EKB Journal Management System, 2022; 28(6.2): 333-338. doi: 10.21608/zumj.2020.31794.1871

Association between viral Conjunctivitis and Genetic Polymorphisms related to IL-4 and IL-4R in Egyptian Population

Zagazig University Medical Journal
Article 43, Volume 28, Issue 6.2, November 2022, Page 333-338  XML PDF (314.55 K)
Document Type: Original Article
DOI: 10.21608/zumj.2020.31794.1871
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Authors
noha said email orcid 1; reda fekry2; hala elmesallmy1
1zagazig university, faculty of science, chemistry department, biochemistry division
2zagazig university, faculty of science, chemistry department.
Abstract
Background: Viral conjunctivitis is an inflammation of the conjunctiva caused by viruses. Interleukin-4 (IL-4) and IL-4R have been reported to associate with the pathogenesis of conjunctivitis; however, the role of IL-4 and IL-4R genetic polymorphisms in conjunctivitis remains unknown. Objective: This study aimed to evaluate the relation between IL-4 gene polymorphisms (rs2243250) and IL-4 gene receptor (rs1805010) with infectious conjunctivitis. Material and methods: The study was conducted in 92 age-matched volunteers; 50 of viral conjunctivitis patients and 42 of healthy controls. The levels of both IL-4 and total IgE were measured using suitable methods. Genotyping of IL-4 (rs2243250) SNP was performed by Alleles Refractory Mutation Systems PCR (ARMS PCR) method, while the Genotyping of IL-4 receptor (rs1805010) SNP was performed by RFLP PCR method. Results: Our results showed that there is a significant difference in genotype and alleles distributions in IL-4 (rs2243250) SNP between viral conjunctivitis and control. However, no significant difference in genotypes and alleles distribution IL-4 gene receptor (rs1805010) SNP between viral conjunctivitis and control. More ever, there is a significant increase in serum IL-4 and total IgE in viral conjunctivitis than control. Conclusion: the analysis of our results indicates that IL-4 (rs2243250) SNP gene polymorphisms may be an indicator of increasing the incidence of viral conjunctivitis in the Egyptian population.
Keywords
conjunctivitis; gene polymorphism; IL-4; IL4R; and viral infection
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