Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis
Kassem, K., Abdelrazik, M., Hashem, H., Abdelkarim, H., Mahmoud, M. (2020). Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis. EKB Journal Management System, 37(2), 432-438. doi: 10.21608/bmfj.2020.97917
Kassem Kassem; Mohsen Abdelrazik; Hamada Hashem; Heba Abdelkarim; Mona Mahmoud. "Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis". EKB Journal Management System, 37, 2, 2020, 432-438. doi: 10.21608/bmfj.2020.97917
Kassem, K., Abdelrazik, M., Hashem, H., Abdelkarim, H., Mahmoud, M. (2020). 'Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis', EKB Journal Management System, 37(2), pp. 432-438. doi: 10.21608/bmfj.2020.97917
Kassem, K., Abdelrazik, M., Hashem, H., Abdelkarim, H., Mahmoud, M. Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis. EKB Journal Management System, 2020; 37(2): 432-438. doi: 10.21608/bmfj.2020.97917

Study of Interleukin 23 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis

Benha Medical Journal
Article 10, Volume 37, Issue 2, June 2020, Page 432-438  XML PDF (597.47 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2020.97917
View on SCiNiTO View on SCiNiTO
Authors
Kassem Kassem1; Mohsen Abdelrazik1; Hamada Hashem2; Heba Abdelkarim3; Mona Mahmoud4
1Department of otorhinolaryngology, Benha faculty of medicine, Benha University, Egypt
2Department of otorhinolaryngology, Benha faculty of medicine, Benha university, Egypt
3Department of biochemistry, Benha faculty of medicine, Benha University, Egypt.
4Department of otorhinolaryngology, Benha health insurance hospital, Egypt
Abstract
Objective: Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in Egyptians. Methods: we included 100 AR patients and 75 control Egyptian subjects in a case-control study. The study involved obtaining blood samples for DNA extraction, genotyping and determination of a selected single-nucleotide polymorphisms in IL-23R by performing TaqMan assay PCR. Results: A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (p 0.001). Conclusions: To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Egyptian population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.
Statistics
Article View: 177
PDF Download: 368