A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance
Mosalam, E., Zidan, A., Mehanna, E., Mesbah, N., Abo-El-Matty, D. (2020). A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance. EKB Journal Management System, 4(2), 32-38. doi: 10.21608/rpbs.2020.23584.1053
Esraa M Mosalam; Abdel-Aziz A Zidan; Eman T. Mehanna; Noha Mesbah; Dina Abo-El-Matty. "A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance". EKB Journal Management System, 4, 2, 2020, 32-38. doi: 10.21608/rpbs.2020.23584.1053
Mosalam, E., Zidan, A., Mehanna, E., Mesbah, N., Abo-El-Matty, D. (2020). 'A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance', EKB Journal Management System, 4(2), pp. 32-38. doi: 10.21608/rpbs.2020.23584.1053
Mosalam, E., Zidan, A., Mehanna, E., Mesbah, N., Abo-El-Matty, D. A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance. EKB Journal Management System, 2020; 4(2): 32-38. doi: 10.21608/rpbs.2020.23584.1053

A:Role of Notch Signaling Pathway in Breast Cancer and Chemo-resistance

Records of Pharmaceutical and Biomedical Sciences
Article 4, Volume 4, Issue 2, July 2020, Page 32-38  XML PDF (778.09 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2020.23584.1053
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Authors
Esraa M Mosalam email orcid 1; Abdel-Aziz A Zidan2; Eman T. Mehannaorcid 3; Noha Mesbahorcid 4; Dina Abo-El-Mattyorcid 5
1Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt
2Zoology Department, Faculty of Science, Damanhour University, Egypt
3Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt
4Biochemistry Department, Faculty of Pharmacy, Suez Canal University, Egypt
5Faculty of Pharmacy - Suez Canal University
Abstract
Despite the advanced treatment strategies, breast cancer remains the second cancer causing mortality across women worldwide. Notch signaling pathway has been found to be emerged in several cancers as well as in acquired and innate drug resistance. Therefore, understanding the role of Notch molecular mechanism could harbor beneficial impact to overcome chemoresistance and developing novel treatment strategies for cancer. Cisplatin (CIS) is an effective chemotherapeutic agent that is widely used against cancer but resistance is frequently occurs with limited therapeutic efficacy. One approach to overcome such unfavorable resistance is using complementary therapies with CIS. Thymoquinone (TQ) is a main compound in the essential oil of Nigella sativa. It has potent oncostatic activity by modulation of multiple regulatory pathways. Pentoxifylline (PTX) is a methylated xanthine derivative with remarkable anti-inflammatory and immunomodulatory actions. Combining TQ and PTX with CIS could be a promising strategy to suppress Notch signaling and overcome CIS resistance.
Keywords
Notch; Cisplatin; thymoquinone; Pentoxifylline; Chemo-resistance
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