Diagnostic Value of Urinary Heparin Binding Protein in Urinary Tract Infection in Children | ||||
| GEGET | ||||
| Article 2, Volume 15, Issue 1, June 2020, Page 10-16 PDF (449.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/geget.2020.19165.1010 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ahmed M El-Refaey1; Amira H Hagar   1; Nermin Y Abo El kheir2; Mayada S Zeid1
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| 1Department of Pediatrics, Mansoura University Children’s hospital, Faculty of Medicine, Mansoura University, Egypt. | ||||
| 2Department of Clinical Pathology, Faculty of medicine, Mansoura University, Egypt. | ||||
| Abstract | ||||
| Introduction Urinary tract infection is one of the most common bacterial infection in infants and children, diagnosis can be missed or delayed as urine cultures are time consuming. Aim of the Study Our aim is to assess the sensitivity and specificity of urinary heparin binding protein (U-HBP) in diagnosis of Urinary tract infection. Methods Acute febrile children with core temperature ≥ 38 for less than 1 week were enrolled, from 1 month to 3 years from January to May 2016. Urinary HBP levels were assessed by ELISA in the supernatant stored aliquots of centrifuged freshly voided urine. Data was analyzed using SPSS 21. Results We found that median levels of U-HBP, were significantly higher in positive focus group in comparison to negative with p value < 0.001, and that there's a significant relationship between the U-HBP and urine culture (gold standard) with good positive and negative predictive value. Conclusion Urinary heparin binding protein can be used as reliable biomarker for the detection of UTI at level 650 picogram/ml in infants and children with sensitivity (72.7%) and specificity (81.2%). | ||||
| Keywords | ||||
| Urinary tract infection; Urinary Heparin binding protein; febrile children; specificity; sensitivity | ||||
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