Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis
Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. (2020). Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis. EKB Journal Management System, 80(2), 820-826. doi: 10.21608/ejhm.2020.98915
Sabry Abd Allah Shoeib; Ayman Fathy Abd ElHalim; Mohamad Ahmad Abd ElHafez; Ashraf Abd ElRaof Dawod; Essam Ali Abd ElMohsen; Sameh Abo ElNasr Abd ElSalam ElBaz. "Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis". EKB Journal Management System, 80, 2, 2020, 820-826. doi: 10.21608/ejhm.2020.98915
Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. (2020). 'Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis', EKB Journal Management System, 80(2), pp. 820-826. doi: 10.21608/ejhm.2020.98915
Shoeib, S., Abd ElHalim, A., Abd ElHafez, M., Dawod, A., Abd ElMohsen, E., ElBaz, S. Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis. EKB Journal Management System, 2020; 80(2): 820-826. doi: 10.21608/ejhm.2020.98915

Serum Soluble Glycoprotein VI (sGPVI) to Predict the 28th Day In-Hospital Mortality in Adult Patients with Sepsis

The Egyptian Journal of Hospital Medicine
Article 11, Volume 80, Issue 2, July 2020, Page 820-826  XML PDF (601.12 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2020.98915
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Authors
Sabry Abd Allah Shoeib; Ayman Fathy Abd ElHalim; Mohamad Ahmad Abd ElHafez; Ashraf Abd ElRaof Dawod; Essam Ali Abd ElMohsen; Sameh Abo ElNasr Abd ElSalam ElBaz*
Abstract
Background: Sepsis is a complicated syndrome resulting from the inappropriate expression of host factors in response to infection and is a major cause of death in patients that are hospitalized in emergency departments and in critical care units.
Objective: The purpose of the present study was to identify the role of serum soluble glycoprotein VI (sGPVI) in predicting the 28th day in-hospital mortality in adult patients with sepsis.
Patients and methods: This observational prospective cohort study included a total of 90 adult patients aged ≥18 years old with clinically suspected sepsis, recruited from Medical Intensive Care Units of Menoufia University Hospital and Kafr El-Sheikh general hospital. The included subjects were diagnosed using quick SOFA score and according to survival at the 28th day, they were divided into two groups; Group A (survivors) consisted of 69 patients (76.7%) and Group B (non survivors) consisted of 21 patients (23.3%).
Results: As regard clinico-laboratory data (qSOFA, sGPVI, SGOT, respiratory rate, ESR, WBCs) and complications (hospital stay), they are significantly increased (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. Concerning platelet count, it is significantly reduced (P value < 0.001) in non-survivor studied patients in comparison with survivor ones. As regard clinico-laboratory data (qSOFA, SGOT, respiratory rate, ESR and WBCs) and complications (hospital stay), they are positively correlated with sGPVI with a statistically significant difference in non-survivor studied patients. Concerning platelet count, it is negatively correlated with sGPVI with a statistically significant difference in non-survivor studied patients.
Conclusion: It could be concluded that glycoprotein VI is a valuable prognostic predictor during sepsis being more reliable than other widely used indicators and severity scores, such as qSOFA, WBCs, platelet count and CRP.
Keywords
Sepsis; sGPVI; qSOFA; CRP
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