Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders
Ebada, H., Nasra, M., Hazzah, H., Youssef, O. (2024). Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders. EKB Journal Management System, 1(2), 100-117. doi: 10.21608/japs.2024.284488.1021
Heba Mohamed Khairy Ebada; Maha Nasra; Heba Hazzah; Ossama Youssef. "Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders". EKB Journal Management System, 1, 2, 2024, 100-117. doi: 10.21608/japs.2024.284488.1021
Ebada, H., Nasra, M., Hazzah, H., Youssef, O. (2024). 'Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders', EKB Journal Management System, 1(2), pp. 100-117. doi: 10.21608/japs.2024.284488.1021
Ebada, H., Nasra, M., Hazzah, H., Youssef, O. Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders. EKB Journal Management System, 2024; 1(2): 100-117. doi: 10.21608/japs.2024.284488.1021

Mucoadhesive buccal tablets incorporating curcumin solid dispersion as a potential approach for enhancing curcumin therapeutic efficacy in oral inflammatory disorders

Journal of Advanced Pharmaceutical Sciences
Volume 1, Issue 2, June 2024, Page 100-117  XML PDF (1016.8 K)
Document Type: Original Article
DOI: 10.21608/japs.2024.284488.1021
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Authors
Heba Mohamed Khairy Ebada email 1; Maha Nasra2; Heba Hazzah3; Ossama Youssef2
1Central Lab, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
2Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
3Department of Pharmaceutics, Faculty of Pharmacy and Drug Manufacturing, Pharos University, Alexandria, Egypt.
Abstract
Curcumin (cur) elicits a wide spectrum of potent responses for local treatment of oral disorders. However, its clinical use in the oral cavity is limited by its poor solubility and chemical instability at salivary pH. This study aims to develop cur mucoadhesive buccal tablet formulation with enhanced cur solubility and stability. For this purpose, a rapidly dissolving solid dispersion (SD) was developed using PVP (Kollidon®25). In addition, chemical stability in phosphate buffer saline (PBS) pH 6.8 was investigated for the first time using different stabilizers to ensure cur stability for in-vitro and in-vivo studies. After addressing solubility and stability challenges, buccal tablets formulations were developed using Hydroxypropyl methylcellulose (HPMC) and Carboxymethyl cellulose (CMC sodium) mixture in different ratios with or without SLS as stabilizer.
Tablets containing HPMC.K15M: CMC sodium (5:1), SD (1:3), and 15 mg SLS showed the best results regarding mucoadhesive strength, in-vivo residence time, and release rate profile and were considered as the optimized formulation. The optimized formulation ensured cur stability as well as a controlled release rate, with considerable cur levels in saliva for over 12h. Preliminary clinical evaluation showed remarkable anti-inflammatory and healing effects in patients with aphthous ulcer, concluding that cur stabilized mucoadhesive formulation can efficiently treat various inflammatory oral diseases.

Highlights
  • Amorphous cur solid dispersion improved cur solubility problem at low expenses.
  • SLS exhibited excellent cur stability in in-vitro and in-vivo studies.
  • Mucoadhesive tablets increased the contact time resulting in rapid pain relief.
  • Cur stabilized mucoadhesive tablet showed a promising healing effect.
Keywords
Curcumin; Mucoadhesive; Stability; Solubility; Buccal delivery
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