Protective effects of date extract against toxic effects of lead acetate in rats | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 61, Issue 3, July 2015, Pages 71-76 PDF (3.05 M) | ||
| DOI: 10.21608/vmjg.2015.373658 | ||
| Authors | ||
| Mahmoud Yasein* 1; El Jakee J2; Mervat M K3; Hussein M Galal2; Tohamy A F4; Marouf Sherif2 | ||
| 1Graduate student, Faculty of Veterinary Medicine, Cairo University | ||
| 2Department of Microbiology, Faculty of Veterinary Medicine, Cairo University | ||
| 3Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University | ||
| 4Department of Toxicology and Forensic Medicine, Faculty of Veterinary Medicine, Cairo University | ||
| Abstract | ||
| Lead (Pb) is a common industrial and environmental pollutant, Prolonged exposure of a sublethal dose to this toxicant is associated with oxidative stress and considered to be a risk factor for kidney and liver in addition to many disorders. This study was carried out to investigate the most toxic effects of lead with a trial to diminish this toxicity by supplementation: of date extract, Both the enzymatic {superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx) glutathione-S-transferase (GSH-T) and catalase (CAT)}, and non- enzymatic (glutathione, GSH) antioxidants has been studied among mature male albino rats which have been received lead acetate in drinking water for 3 months. It is widely accepted that even small quantities of Pb are harmful to rats which is implicated in a broad range of physiological conditions. The study proved that the use of date extract, through its antioxidant protective effect and immune potentiating properties, can reduce Pb-induced hepatic damage and toxicity. | ||
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