SEDATIVE, ANALGESIC, HEMATOLOGICAL AND BIOCHEMICAL EFFECTS OF ROMIFIDINE IN CAMELS (CAMELUS DROMEDARIES). | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 55, Issue 1, January 2007, Page 9-23 PDF (5.03 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2007.378403 | ||||
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| Authors | ||||
| H MOHSEN* 1; M MARZOUK2; M ABUZEAD3 | ||||
| 1Dept. Surgery, Anesthesiology and Radiology. Faculty of Vet. Med., Kafer-Elsheikh University | ||||
| 2Depart. Surgery, Anesthesiology and Radiology | ||||
| 3Depart. Physiology**, Faculty of Vet. Med., Suez Canal Univy. | ||||
| Abstract | ||||
| The present study was done on 12 clinically normal camels. The main objective was to evaluate the clinical usefulness, sedative, analgesic, hematological and biochemical effects of 3 dose rates of romifidine administrated intravenously (IV) in camels. Camels were divided into 3 groups. Each group (n=4) was specified for one dose level of romifidine (40, 80 and 120 pg/kg body weight). Heart and respiratory rates, ruminal movements, muscle relaxation, response lo auditory and tactile stimulations and degree of ataxia were recorded immediately (time 0) before administration of romifidine, 15, 30, 45, 60, 90, 120 and 180 minutes. The time of onset, degree and duration of sedation and analgesia were recorded for 3 hours after drug administration. Blood samples were collected at the same times of the clinical observations for determination of hemoglobin (Hb %), packed cell volume (PCV %), RBCs and WBCs counts. Blood plasma was analyzed for blood glucose concentration. Blood serum was also analyzed for blood urea nitrogen and creatinine concentrations. The obtained results indicated significant decrease in heart rate, ruminal movement, head height and response to auditory and tactile stimuli. Meanwhile, significant increase in degree of ataxia, distance between the ear tips and blood glucose concentration were recorded after administration of romifidine. No significant changes in rectal temperature, respiratory rate Hb %, PCV %, WBCs and RBCs counts | ||||
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