Potassium competitive acid blocker based sequential therapy in treatment of naïve and previously treated patients with H. pylori infection | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 07 January 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.339992.2370 | ||||
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| Authors | ||||
Ahmed Abo Zaid Teima1; Randa Mohamed Sedeek 1; Zeinab Abdelaziz Kasemy 2; Noran Talaat Abo El Khair3; Khaled Abdel Aty4; Housam Ahmad Helmy5; Ahmed Shaban5; Heba Mostafa El Hagary  1
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| 1Tropical Medicine Department, Faculty of Medicine, Menoufia University, Shebin El- Kom, Egypt | ||||
| 2Public Health and Community medicine department, Faculty of Medicine, Menoufia university, Egypt | ||||
| 3Clinical Pathology department, Faculty of Medicine, Menoufia university, Egypt | ||||
| 4Internal Medicine Department, Gastroentrology Unit, Faculty of Medicine, Alexandria university, Egypt | ||||
| 5Hepatology and Gastroenterology Department, National Liver Institute, Menoufia university, Shebin El- Kom, 32511, Egypt | ||||
| Abstract | ||||
| Background: Helicobacter pylori (H. pylori) colonize the gastric lining and cause gastrointestinal disorders. Treatment of H. pylori has developed lately to improve eradication rates. Our objective was to evaluate potassium competitive acid blocker based sequential therapy in treatment of naïve and previously treated patients with H-pylori infection. Methods: Prospective cohort study included 180 patients diagnosed with H. pylori infection either naïve or previously treated were divided into 4groups. Group I included naïve patients received traditional therapy (PPI 40mg once daily,clarithromycin500mg twice daily & metronidazole 500mg twice daily)for 14days, group II included naïve patients on P-CAB based sequential(5 days of vonaprazan 20mg twice daily, moxifloxacin 400 mg once daily, nitazoxanide 500 mg twice daily, followed by 5 days of vonaprazan 20mg twice daily, levofloxacin 500mg once daily & metronidazole 500mg twice daily), group III included previously failed treatment patients received P-CAB based sequential, and group IV included previously treated patients on LOAD therapy(10 days of omeprazole 40mg once daily, levofloxacin 500mg once daily, nitazoxanide 500mg twice daily, & doxycycline 100mg twice daily). H.pylori stool antigen test done at the time of diagnosis and after 4- 6 weeks after end of treatment. Results: The cure rate among the studied groups was higher in GII (93.3%) followed by GIII (88.9%), then GIV (71.1%) and the least response is GI (62.2%). Conclusion: P-CAB based sequential regimen was the highest eradication rate and least side effects in comparison with traditional and LOAD therapy. | ||||
| Keywords | ||||
| P-CAB based sequential therapy; H. pylori; LOAD therapy; traditional therapy | ||||
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