Preparation, Characterization and Evaluation of a Poly Methyl Methacrylate Bone Cement Modified by Montmorillonite Loaded with Silver Nano Particles | ||||
| Al-Azhar Journal of Dentistry | ||||
| Volume 2022, Issue 3, July 2022 | ||||
| DOI: 10.21608/adjg.2022.76299.1391 | ||||
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| Authors | ||||
| Horia Elsherif1; Sayed Saniour2; Inas Motawea3; Hisham Essawy4; Mostafa Abd El-Gany5; Dalia Zaki6 | ||||
| 1Assistant Researcher at Restorative and Dental Biomaterials Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt. | ||||
| 2Professor of Dental Materials, Faculty of Dentistry, Cairo University, Cairo, Egypt. | ||||
| 3Professor of Dental Biomaterials, Dean of Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt. | ||||
| 4Professor of Polymer Science, Department of Polymers and Pigments, Institute of Chemical Industries Research, National Research Centre, Cairo, Egypt. | ||||
| 5Professor of Removable Prosthodontics, Faculty of Dental Medicine for Girls, Al-Azhar University. | ||||
| 6Professor at Restorative and Dental Materials Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt. | ||||
| Abstract | ||||
| Purpose: The aim of this study was to prepare and characterize poly methyl methacrylate (PMMA) composite bone cement filled with montmorillonite (MMT) and loaded with silver nanoparticles (AgNPs). Materials and methods: AgNPs were synthesized by the chemical reducing method. Characterization was done using Field emission scanning electron microscope (FE-SEM), X-ray diffraction analysis (XRD) and Thermogravimetric analysis (TGA). Two and four weight percentages of MMT powder and the prepared MMT/AgNPs powder were added to the bone cement.A total of 75 PMMA bone cement specimens were prepared and divided into 5 groups (control group, PMMT/MMT 2%, PMMT/MMT 4%, PMMT/MMTAgNps 2% and PMMT/MMTAgNps 4%). Then they were tested regarding the compressive strength, flexural strength and antibacterial activity. Results: SEM images showed the layered MMT with light spots indicating presence of AgNPs that was confirmed by XRD; while TGA showed its thermal stability. Compressive strength results revealed statistically insignificant difference between the control and the tested groups while the 4% PMMA/MMT showed statistically significant higher values than the 2%. Statisticallyinsignificant difference in flexural strength results were found between the 2% and 4% concentrations within the PMMA/MMT/AgNPs group, and within the PMMA/MMT group. Antibacterial results revealed statistical significant differences in all the tested groups (p < 0.001). Conclusion: MMT could be used as a controlled delivery system to hold AgNPs that proved to have antibacterial effect when added to PMMA cement. Addition of 4% MMT to PMMA bone cement improved its compressive strength. | ||||
| Keywords | ||||
| polymethyl methacrylate; silver nanoparticles; montmorillonite | ||||
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